Salk Institute for Biological Studies

  Application Instructions: Employment History  Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The objective of this position is to perform the computational neuroscience research and scientific software programming tasks required to support the MCell project (mcell.org). The project researcher receives direction for major project goals and requirements from the project leaders. The incumbent should be a highly self-motivated individual with well-developed leadership, organizational, and communication skills, as well as work well in a team. ESSENTIAL FUNCTIONS   (100%) Computational Neuroscience Research and Scientific Software Programming Interface with MCell project leaders to...

  Application Instructions: Employment History  Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY Under direct supervision, the Research Assistant I position is part of a multidisciplinary team studying epigenetics, chromatin structure, and gene expression.  Responsibilities include, but are not limited to, performing techniques related to cell and molecular biology and biochemistry. Tasks include maintenance of tissue, DNA, and other experimental samples, as well as taking part in data analysis and experimental planning.  Other duties include assisting with general laboratory maintenance, including equipment maintenance, and ordering of supplies, etc. LABORATORY SUMMARY The Dixon Lab seeks...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY Oversee the administrative and organizational management of the project. Serve as the vital nexus between the trainees and the PIs, part of this large cooperative U19 grant, and have a key role in supporting the team and the achievement of the grant milestones. Coordinate and work closely with lab managers, PIs and trainees for ensure the sustained productivity on the grant. Optimize design of experiments and research strategies for electrophysiological analysis and interface with the computational team to optimize the modelling effort. ESSENTIAL FUNCTIONS   1) (50%) Project Management for Grant   Partners closely...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Integrative Genomics and Bioinformatics Core (IGC) provides computational analysis support for omics projects at the Salk Institute. This includes training in genomics analysis, development of novel algorithms and approaches, active collaborative participation in research projects with laboratories across the Institute, maintenance of core resources, and providing training in interpretation and design of high-throughput experiments. The core works closely with the Next Generation Sequencing Core (NGS), Mass spectrometry core (MASS), Information Technology (IT), scientific, administrative, and core leadership to facilitate...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY A Project Scientist position is immediately available at the Salk Institute for Biological Studies in San Diego, California. The Project Scientist will be working with Professor Shadel, who studies the basic biology of mitochondria and mtDNA, and, in doing so, has identified novel ways that mitochondria contribute to disease, aging and the immune system. The Project Scientist will pursue a project to understand the regulation of human mitochondrial gene expression, including transcription, processing and post-transcriptional modifications of mtDNA-encoded RNAs. Project Scientists make significant contributions to a research...

  Application Instructions: Employment History  Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. Job location is in Salk North (Torrey Pines) POSITION SUMMARY Under the direct supervision of the Sr. Director, Finance (FIN), this position will provide experienced administrative and clerical support to multiple supervisors and staff of the Finance, Research Accounting, Procurement, and Financial Information Systems departments in a high-volume environment.  The ideal candidate will be a self-starter with excellent attention to detail, leveraging strong organizational skills to manage shifting priorities and effective communication skills to coordinate with a broad spectrum of internal and external stakeholders....

  Application Instructions: Employment History  Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. Job location is in Salk North (Torrey Pines) POSITION SUMMARY With general guidance, the Sr. Human Resources Partner is responsible for providing experienced-level Human Resources (HR) support to assigned administrative and/or laboratory client groups with regard to all phases of the employment and personnel lifecycle.  Works closely with department heads, managers, and supervisors to ensure seamless, effective, and timely delivery of HR services.  Provides HR counsel to personnel at all levels.  Duties include leading the assessment, advisement, and execution on a variety of HR matters including personnel...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY Under general supervision, position performs tasks and experiments in support of academic research projects. Responsibilities may include: routine molecular biology, biochemical, and cell biology techniques. Maintains and prepares accurate records of all experiments. Assists with lab maintenance such as cleaning of laboratory glassware, sterilization of materials and preparation of solutions. ESSENTIAL FUNCTIONS (100%) Lab Support Assist with general laboratory organization and maintenance, duties include but are not limited to, restock media, autoclave tubes, refill jars, dispose of boxes and waste, clean water...

Post-doctoral position available for individual interested in signal transduction, transcriptional regulation, and metabolism. Experience in RNA sequencing, chromatin immunoprecipitation, and in bioinformatics helpful. Candidate should enjoy working independently in a collaborative setting. Interest in metabolic physiology desirable; we have state of the art facilities to study the role of the CREB pathway in different metabolic states. Our lab also employs genetics to gain insight into the role of the CREB pathway in glucose and lipid metabolism as well as in the development of insulin resistance and type II diabetes. We use biochemical approaches to characterize regulatory components of the CREB pathway and to identify cellular CREB target genes that contribute to the underlying physiology. Mice with knockouts of CREB and CRTC family members in different tissues are employed to identify biological contexts in which this pathway is activated. Interested applicants with PhD or...

The McVicker laboratory studies how human genetic variation affects gene regulation by combining experimental approaches with computational analyses. We are especially interested in identifying pathogenic regulatory variants that act in immune cells and cancer cells. Currently, we are developing new tools to discover somatic regulatory mutations in cancer genomes, and manipulating cell lines with high-throughput CRISPR technologies to discover new regulatory sequences. In much of our research, we develop sophisticated computational and statistical methods so that we can extract subtle signals from noisy experimental data. Position Description:   Quantitative trait mapping of single cell gene expression and chromatin traits The McVicker Laboratory at the Salk Institute for Biological Studies is seeking a postdoctoral fellow to tackle cutting-edge research problems in genetics, gene regulation and chromatin biology. The successful candidate will develop new statistical...

The goal in the lab is to understand the molecular and circuit mechanisms of reward-based action learning, focusing on the cortico-basal ganglia circuitry and dopamine function. Position Description:   We are currently seeking a highly motivated and independent postdoctoral fellow interested in studying the basal ganglia circuits and behavior. Research in the laboratory focuses on the molecular and circuit mechanisms of action learning and selection, using a combination of behavioral, optogenetics, slice/in vivo electrophysiology and imaging techniques. The successful candidate will employ electrophysiology and/or deep-brain imaging, together with viral tracing and optogenetics to dissect the function of specific cell types of basal ganglia circuitry in freely behaving mice. Education:   The candidate should hold a doctoral degree with a strong background in systems or cellular neuroscience. Experience:   Experience on slice or in vivo electrophysiological...

Nearly every facet of human experience is colored by the sense of sight. The effortlessness and immediacy with which this sense conveys physical, social, and aesthetic qualities of one's environment belie the extraordinary complexity of the brain mechanisms involved. Our acute dependence upon these mechanisms is brought to the fore, however, by a variety of developmental, traumatic, and disease-related disorders of visual perception and visually-guided behavior. While rarely life- threatening, such disorders can be profoundly debilitating, impairing activities that we have come to take for granted, such as reading, driving, or recognizing family and friends. We seek a thorough understanding of brain mechanisms of visual information processing, with the promise of effective treatment and remediation of disorders of vision, as well as insights into the nature of our conscious experience of the world. The specific aims of our research have been to identify how sensory signals in...

The research focuses on important problems related to cancer initiation, detection, progression, metastasis and treatment. These projects are based on our recent observations concerning cell state plasticity that arises during cancer progression. Specifically, we are using a single cell RNA sequencing, epigenetic profiling, and developing novel in vivo and in vitro strategies involving mouse models and organoid cultures to determine how cancer cells undergo developmental reprogramming to generate intra-tumoral heterogeneity and metastasis. We use computational methods based on mouse cancer models and human databases. Our work has focused significantly on breast cancer, but new studies have taken us into exciting directions involving cell state reprogramming involving acinar-ductal metaplasia in the genesis of pancreas cancer. Our long-term goals are to devise novel strategies to intercept cells undergoing reprogramming to reduce the probability that drug resistant or metastatic...

Position Description:   A postdoctoral researcher/bioinformatics specialist position is immediately available for three years to lead a project focused on tissue-specific and temporal variation in gene expression. The candidate will work in a highly collaborative team of researchers at Salk and at collaborating institutes in the U.S. Position Tasks: Compile large scale multi-tissue time-series gene expression data from rodents and non-human primates. Analyze full-length transcripts to find splice variants. Integrate gene expression and genome sequence data to find cis-acting elements. Integrate gene expression and genome sequence information to find allele specific gene expression. Comparative genomics between non-human primate, human, and rodent models. Integrate and analyze time-series gene expression and metabolomics datasets. Manage project to meet defined milestones and timeline. Coordinate efforts among the wet-lab and sequencing cores to ensure...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. Description:   The Kosuri Lab at the Salk Institute for Biological Studies seeks to recruit multiple Postdoctoral Fellows to engage in integrative biology research. The lab has two tracks: 1) single-molecule studies of protein-DNA interactions, using methods based on DNA origami and super resolution microscopy; and 2) Cardiac biology studies in mouse models and humans, using genetic and imaging approaches including new methods for single-cell spatial transcriptomics. The postdoctoral positions are for scientists looking to invent and deploy new technology to uncover foundational principles in biology. Ideal candidates are excited to join a...

The Chalasani lab at Salk is seeking ambitious and motivated post-doctoral fellows to join their Sonogenetics team. The goal of this project is to develop a new non-invasive method to manipulate neurons and non-neuronal cells ( www.sonogenetics.salk.edu ). Our manuscript demonstrating the efficacy of this method in mice was recently posted on bioarxiv ( https://www.biorxiv.org/content/10.1101/2020.10.14.338699v1 ).  We are planning to identify and validate new channel candidates and variants for use across model systems to achieve both excitation and inhibition non invasively.  Additionally, this project involves collaborating with engineers, bioinformaticians, protein biochemists and theoretical modelers.  We are particularly interested in individuals with expertise in electrophysiology (in vitro and in vivo) and/or mouse behavior and neural circuit analysis. Please contact the PI ( schalasani@salk.edu ) with your resume and names of referees who can speak to your skills.

Position description Our research employs cross-disciplinary approaches (genetics, transcriptomics, circuit tracing, functional imaging, quantitative behavioral analyses) to elucidate the roles played by genes and neurons in social behavior. An ideal postdoctoral fellow candidate would have a demonstrated expertise in the following fields: Biochemistry and bioinformatics. We seek a candidate who has both bench and quantitative data analysis experience in transcriptomics. Using our 10X Genomics single cell transcriptome platform, we intend to characterize genes responsible for flexible behavioral modulations during social interactions in both flies and unconventional animal models, such as honey bees and paper wasps. Neurophysiology. We seek a candidate who is familiar with techniques for monitoring activities of neurons in vivo , such as electrophysiology and functional imaging. We are in the process of expanding our functional imaging capacity to be able to monitor...

The Engle Lab focuses on understanding the etiology of pancreatitis and pancreatic cancer to develop better prevention, diagnostic, and treatment strategies. We study the impact of altered glycosylation on the cross-talk between ductal cells with their microenvironment during disease pathogenesis as well as the role of tobacco-related carcinogens in priming the pancreas for transformation. We rely heavily on three-dimensional organoid mono- and co-culture systems as well as genetically engineered mouse models.  Position Description Post-doctoral positions are immediately available for individuals with a good understanding of cancer and disease modeling. Ideal candidates should be intellectually curious, well-organized and well-versed in constructive problem solving. Experience with cell culture and mouse modeling is preferred. Education:   Ph.D. or M.D./Ph.D. in Biological Sciences or related fields.  

The Stites Laboratory applies quantitative and systems approaches (both experimental and computational) to the study of cancer.  We primarily focus upon the RAS pathway due to its importance in cancer, the abundance of data on the pathway and its molecular components, and the ready availability of excellent reagents and methods.  We repurpose these data and methods to study RAS from a systems perspective.   The laboratory is comprised of both experimental biologists and computational biologists. Position Description:   The postdoctoral fellow will be the primary lead for a new research program in the laboratory.  The research project(s) in this program will extend the lab's established expertise in RAS biology, cancer biology, personalized medicine, and computational systems biology into the field of synthetic biology.  Envisioned projects will utilize a synthetic biology approach to investigate cancer development and new cancer treatment strategies.  The postdoctoral...

Laboratory research focuses on how genes and molecules orchestrate the development of an embryo. The knowledge obtained may help to discover new molecules and specific gene/cell treatments to prevent and cure diseases affecting mankind both in the adult and embryonic stages, as well as inducing endogenous in vivo regenerative responses that may allow for tissue and organ regeneration and slowing down the aging process. Position Description:   Funded post-doctoral positions are immediately available for individuals with a good grounding in molecular and/or developmental biology, methods such as CRISPR mediated genome editing, RNA sequencing and epigenetics. Knowledge of bioinformatics is also very desirable. Ideal candidates should be intellectually curious, productive, and enjoy working in a committed team effort to make these important projects succeed. The projects are well under way due to the efforts of a dedicated group of post-docs, technicians and undergrads....