Salk Institute for Biological Studies

Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Regulatory Biology Laboratory at the Salk Institute uses data science tools to analyze large scale data ranging from RNA seq, DNA seq to human lifestyle datasets from food image analyses. The Data scientist position will work closely with other members of the lab and the PI to advance genomics and related research projects.  A significant effort will be on standardizing methods to collect, process, sequence, and analyze RNA or DNA sequencing from animal and human tissues to address specific research questions. The position will manage the RNA-seq and DNA-seq data science needs of in the...

Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY: Position available in the Hargreaves Lab for overall lab management duties in support of the Principal Investigator’s (PI) studies. General lab maintenance duties include maintaining adequate inventory of materials and equipment to ensure adequate supplies for experimental needs, ordering supplies, taking inventory, upkeep and safety. Position is also responsible for performing various molecular biology, biochemistry, and cell biology techniques in support of lab and PI research goals. Range of duties include, but is not limited to: conducting procedures, modifying procedures as...

Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY: Position available in the Hargreaves Lab for overall lab management duties in support of the Principal Investigator’s (PI) studies. General lab maintenance duties include maintaining adequate inventory of materials and equipment to ensure adequate supplies for experimental needs, ordering supplies, taking inventory, upkeep and safety. Position is also responsible for performing various molecular biology, biochemistry, and cell biology techniques in support of lab and PI research goals. Range of duties include, but is not limited to: conducting procedures, modifying procedures as...

Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The overall goal of the project is to investigate the molecular and physiological effects of time restricted feeding in mice across aging. The intern will be processing mouse samples obtained from previous experiments as well as help conduct new experiments. The intern will also help with general lab maintenance, buffer preparation and stocking. ESSENTIAL FUNCTIONS 1) (70%) Sample processing Grinding of previously collected mouse tissues RNA extraction from various mouse tissues RNA quantification and quality check 2) (15%) Molecular Biology Techniques DNA...

Description   Application Instructions: Employment History   Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION DESCRIPTION This position is responsible for the basic daily husbandry operations in all facilities and with all species in accordance with standard operating procedures and training to ensure compliance with the Guide for the Care and Use of Laboratory Animals, the Animal Welfare Act and Regulations as well as all applicable federal, state, local and institutional laws, regulations, policies  ESSENTIAL FUNCTIONS Husbandry (75%) AHT II, LEVEL A: PROVIDES ADVANCED CARE AND HUSBANDRY FOR ALL RODENT SPECIES Performs daily health and husbandry observations, change cages,...

Description   The Opportunity: Melding the principles of directed evolution and engineering to rationally design novel biological devices —macromolecules, viruses, and cells — that transform the detection and treatment of diseases ranging from genetic syndromes to cancer, inflammation and infectious disease. The Need:  We now know the underlying genetic and molecular targets that cause many devastating diseases, such as, cancer, inflammation and infection. Yet we grapple with a frustrating challenge: for most of these diseases, there are no effective treatments, much less cures. We desperately need new therapies that overcome the limitations of traditional small molecule drugs.  To conquer disease, we need medicines that are as biologically sophisticated as the diseases themselves. Our Approach:  Design is the ultimate test of understanding; to engineer new life, the defining act of creativity. The aspirations of the...

Job Details Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY Provides general administrative (executive level) support to multiple PIs and affiliated lab group including lab management, grant writing, editing and general administrative assistance. Uses initiative, resourcefulness and good judgment to handle a wide variety of administrative and support duties such as project management, addressing inquiries, maintaining filing systems, processing paperwork, composing correspondence and coordinating meetings and travel arrangements. Serves as liaison to Administrative units (Payroll, Human Resources, Grant administration, Computing,...

Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY This position is responsible for the strategies around assessment, research, design, creation and delivery of learning and development programs and initiatives that are relevant, timely, relatable, and measurable so that learning is embedded into the fabric of Salk for all members of the Salk community.  Planning and building momentum and support for initiatives by providing tools and avenues for supervisors to own, create/facilitate and reinforce learning through application will be critical. The incumbent will focus first and until further notice on strategies to meet the most pressing...

Description   The Lyumkis Laboratory applies cryo-EM methods for structure determination of macromolecular assemblies involved in viral infection and chromatin regulation. The Manor Laboratory at the Waitt Advanced Biophotonics Center applies advanced imaging probes and microscopy techniques to visualize the inner workings of cells. We are seeking two postdoctoral candidates to work jointly with us, in conjunction with the cryo-EM facility at The Scripps Research Institute, to develop and apply novel imaging and analysis pipelines for coupling live cell dynamics with focused ion beam milling, cryo-ET, and image analysis of macromolecular assemblies in situ. Position Highlights:  Broadly involved in exciting projects to visualize macromolecular assemblies in cells using integrated structural and cellular biology approaches Utilize an array of advanced tools in live-cell and cryo-fluorescence microscopy, focused ion beam milling, cryo-electron...

Description   The Chalasani lab at Salk is seeking ambitious and motivated post-doctoral fellows to join their Sonogenetics team. The goal of this project is to develop a new non-invasive method to manipulate neurons and non-neuronal cells ( www.sonogenetics.salk.edu ). Our manuscript demonstrating the efficacy of this method in mice was recently posted on bioarxiv ( https://www.biorxiv.org/content/10.1101/2020.10.14.338699v1 ).  We are planning to identify and validate new channel candidates and variants for use across model systems to achieve both excitation and inhibition non invasively.  Additionally, this project involves collaborating with engineers, bioinformaticians, protein biochemists and theoretical modelers.  We are particularly interested in individuals with expertise in electrophysiology (in vitro and in vivo) and/or mouse behavior and neural circuit analysis. Please contact the PI ( schalasani@salk.edu ) with...

Job Details Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Research Assistant is responsible for performing tasks and experiments in support of academic research projects. The position is responsible for maintenance of neurobiology techniques in support of the lab and the Principal Investigator's (PI) research goals. The RAI will be responsible for lab ordering. Manages the mouse colony and oversees other personnel conducting colony management and genotyping. Responsible for maintenance of molecular biology, cell culture, histological processing, microscopy and surgical supplies, equipment and facilities. Performs molecular biology...

Job Details Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY Position is responsible for performing semi-skilled cleaning of a variety of facilities on campus including, but not limited to: laboratories, offices, rest rooms, lounges, hallways, and stairwells to ensure a clean, professional and safe working environment.  Position assists with the cleaning and maintenance of tools, equipment and work area.   General labor duties on a routine and/or regular basis based on operational needs are required. Position is tasked with observing and exercising professionalism established and Institute unique safety...

Job Details Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY Position assists the Assistant Director, Security & Environmental Services with day-to-day activities of assigned shift which include: maintaining the overall security of the Institute campus, ensuring all shifts are covered and personnel are performing shift duties, overseeing the opening and closing of the Institute at designated times, notifying the appropriate persons or dispatcher on duty of unusual occurrences and malfunctioning of machinery or equipment. Responds to and investigates as dispatched, any incident or emergency, and responds to and investigates any...

Job Details Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY Intern will be responsible for programming and data analysis in support of PI research projects. This position is temporary and the term of the initial assignment is anticipated to be up to one year. ESSENTIAL FUNCTIONS Programming and Data Analysis (100%) Responsible for implementing scripts and software pipelines for the analysis of genomics data Communicate results of data analysis to Principal Investigator and other members of the laboratory. Occasionally present results at laboratory meetings. Responsible for debugging and maintaining software...

Job Details Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY :  Position is responsible for the fiscal management and post award responsibilities as it pertains to complex fund management for various types of award mechanisms to include large multi-investigator projects, federal contracts, sponsored research agreements and gifts. Post award oversight and management of our federal contracts.  Detailed award review for compliance and reporting requirements.  Communicates with faculty and senior administration on FAR/DFAR topics as they relate to post award administration and ensures department is compliant. ...

Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Research Assistant I position is responsible for performing various molecular biology, genetics, behavioral assays, cell and biochemistry techniques; C. elegans handling and maintenance in support of the Principal Investigator (PI) and lab research goals. Other duties include assisting with general laboratory maintenance, including equipment maintenance, and ordering of supplies, etc. (30%) Molecular and Cellular Biology, and Biochemistry Techniques Molecular cloning (Standard methods and Gibson cloning) Western blotting (Southern blotting optional, but desired) Purification...

Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY Under general supervision, the Building Service Engineer trade classification has responsibilities that support operation, maintenance and repair of HVAC and refrigeration equipment/systems and related building automation systems. Incumbent must be able to proficiently use building automation systems to diagnose and troubleshoot problems; estimate cost, time and materials for projects; participate in the maintenance and operations of applicable heating and air conditioning systems and equipment; maintain and service tools and equipment used in the performance of duties; perform all work in...

Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. ESSENTIAL FUNCTIONS (75%) – Payroll processing Process in-house bi-weekly and semi-monthly payroll. Run payroll calculation process, review all output, make necessary changes prior to closing payroll. Print payroll checks and sort for delivery to laboratories and departments. Review daily PARs. Calculate and enter required retroactive amounts and other changes into the payroll system. Enter garnishments into the payroll system. Review time management audit reports as needed; contact employees about possible errors/corrections needed; enter adjustments. Enter tax exemptions...

Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Research Assistant II is responsible for research support and some lab management duties in support of the Principal Investigator’s (PI) studies along with duties involving molecular biology, biochemistry, protein production, purification, and some tissue culture work. Duties include performing advanced molecular biology and biochemistry for protein production, purification, and for biochemical assays, as well as some tissue culture work in support of research projects, assisting the postdoctoral associates with experimental design and direction, assisting in hiring new staff, supervising...

Description   Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The part-time Intern position is intended to learn and assist with routine lab support. Under general supervision, activities include: collects and prepares mouse DNA samples for analysis; prepares solutions and media under sterile conditions; performs various molecular biology techniques; and assists with general laboratory maintenance, including equipment maintenance and ordering/stocking of supplies.  This position is temporary and the term of the initial assignment is anticipated to be up to one year.  ESSENTIAL FUNCTIONS (70%) Collection/Preparation of mice DNA samples...