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Salk Institute for Biological Studies

Every cure has a starting point. The Salk Institute embodies Jonas Salk’s mission to dare to make dreams into reality. Its internationally renowned and award-winning scientists explore the very foundations of life, seeking new understandings in neuroscience, genetics, immunology, plant biology and more. The Institute is an independent nonprofit organization and architectural landmark: small by choice, intimate by nature and fearless in the face of any challenge. Be it cancer or Alzheimer’s, aging or diabetes, Salk is where cures begin.


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Mar 27, 2023
Full time
Intern - Molecular Neurobiology Laboratory - Dr. Nicola Allen
Salk Institute for Biological Studies San Diego, CA, USA
SUMMARY: The intern position will engage in a hands-on neuroscience research opportunity in the Molecular and Neurobiology Laboratory of Dr. Nicola Allen. The Intern position will research and focus on studying a class of non-neuronal cells called astrocytes and their roles in regulating brain function. The intern position will specifically work on a project led by a senior PhD student investigating the contributions of astrocyte lipid metabolism to synaptic deficits in aging and Alzheimer's Disease. DUTIES AND RESPONSIBILITIES: Cell culture qPCR analysis Immunostaining Performs other related duties as assigned by supervisor. SUPERVISORY RESPONSIBILITIES: This job has no supervisory responsibilities. QUALIFICATIONS: No prior experience or training. Currently enrolled at college pursuing a Bachelor's Degree (BA) Computer skills required: (Microsoft Office) COMPETENCIES: Dependability - Follows instructions, responds to...
Mar 24, 2023
Full time
Research Assistant II, Immunobiology and Microbial Pathogenesis, Dr. Daniel Hollern
Salk Institute for Biological Studies San Diego, CA, USA
POSITION SUMMARY The Research Assistant II position is responsible for, with limited instruction for routine work, performing various cell and molecular biology and biochemistry techniques; library prep,  mouse handling and colony maintenance, minor mouse surgeries, mouse breeding and weaning, genotyping, flow cytometry and cell sorting, ELISA, single-cell RNA expression analysis in support of the Principal Investigator (PI) and lab research goals. Range of duties include, but is not limited to, data analysis and data base management, maintenance of tissue, DNA, and other experimental samples, assisting with general laboratory maintenance, including equipment maintenance, and ordering of supplies, and training of new personnel. Duties also include establishing and performing research and analysis on projects that involve the study of human and murine B cells.  May provide task instruction, training, and guidance to lower level personnel. May work on...
Mar 22, 2023
Full time
Postdoctoral Fellow, AHA-Allen Brain Health and Cognitive Impairment Initiative
Salk Institute for Biological Studies San Diego, CA, USA
  Join the AHA-Allen Brain Health and Cognitive Impairment Initiative at the Salk Institute Nine laboratories at the Salk Institute have joined forces to understand how aging contributes to Alzheimer's disease (AD) and other age-associated neurodegenerative conditions. This highly interactive team is seeking talented postdoctoral fellows who can work across disciplines (and potentially in multiple labs) to tackle this important problem. Our group is highly resourced and committed to translating what we know about the hallmarks of aging into a new understanding of AD, with the goal of developing novel biomarkers and potential therapeutics. The team has expertise in multiple cell biological systems dysregulated in aging (e.g., inflammation, mitochondria, metabolism, DNA damage/repair, and epigenetics) and is exploring how they interact and contribute to AD and why aging is its biggest risk factor. Experiments are being performed using innovative human cell...
Mar 21, 2023
Full time
Electrician
Salk Institute for Biological Studies San Diego, CA, USA
SUMMARY: Under general supervision, performs the full range of skilled journey level electrical and related work including the installation, maintenance, modification and repair of electrical apparatuses, equipment, and systems. Acts independently and responds with acquired skill, exercising Institute and professionally established safety procedures.   DUTIES AND RESPONSIBILITIES : Organizes and coordinates electrical projects; installs, maintains, and repairs lighting fixtures, and controllers, conduit, receptacles, switches, magnetic starters, PLC's, electrical panels, switchgear, motors, transformers, VFD's, power supplies, and other electrical devices in accordance with the NEC. Inspects circuits and wiring for specified shielding & grounding and repair or rewire plant equipment systems according to code. Repair and maintain all facility electrical wiring and fixtures, major equipment and electrical distribution in accordance with...
Mar 21, 2023
Full time
Crop and Field Senior Research Scientist, Laboratory of Dr. Wolfgang Busch
Salk Institute for Biological Studies San Diego, CA, USA
The Salk Institute's Crop and Field Senior Research Scientist will be responsible for designing, executing, and analyzing select crop root diversity screens and all field trials within Salk's Harnessing Plants Initiative (HPI). The CFSRS performs a lead role in facilitating the HPI Principal Investigators (PI) in identifying and proving concepts related to HPI objectives spanning agronomy, plant biology, genetics, epigenetics, biochemistry, genomics, soil science, associated greenhouse facilities, and multiple academic and commercial collaboration partner relationships. They serve as a vital piece in the discovery pipeline - from the lab to the greenhouse to the field. The CFSRS will be intimately involved in managing multiple field projects, budgeting, data storage, project milestones, and deliverables. They will also be responsible for design and execution of experimental procedures appropriate to the goals of multiple projects and work closely with other the...
Mar 16, 2023
Full time
Research Assistant II - Gene Expression Laboratory, Dr. Ronald Evans
Salk Institute for Biological Studies San Diego, CA, USA
The Research Assistant II position will work both independently and collaboratively as part of a focused group of researchers that studies how epigenetic regulation and the tumor microenvironment contribute to pancreatic cancer progression and therapeutic responses. DUTIES AND RESPONSIBILITIES: Assists with In Vivo Tumor Biology and colony maintenance including genotyping, animal husbandry, and monitoring. Performs cellular and molecular biology techniques which can include Cell Culture, flow cytometry, CRISPR/Cas9 screening, etc. Analyzes and interprets scientific data using a variety of techniques including Ultrasound analysis, Western blot, and DNA and RNA expression. Performs related laboratory support and maintenance such as assisting with preparing standard solutions, stocking and weekly inventory, and organizing incoming lab supplies. Performs other related duties as assigned by management. SUPERVISORY RESPONSIBILITIES: This job has...
Mar 16, 2023
Full time
Research Assistant I - Gene Expression Laboratory - Dr. Ron Evans
Salk Institute for Biological Studies San Diego, CA, USA
The Research Assistant I position will work both independently and collaboratively as part of a focused group of researchers that studies how epigenetic regulation and the tumor microenvironment contribute to pancreatic cancer progression and therapeutic responses. DUTIES AND RESPONSIBILITIES: Assists with In Vivo Tumor Biology and colony maintenance including genotyping, animal husbandry, and monitoring. Performs cellular and molecular biology techniques which can include Cell Culture, flow cytometry, CRISPR/Cas9 screening, etc. Analyzes and interprets scientific data using a variety of techniques including Ultrasound analysis, Western blot, and DNA and RNA expression. Performs related laboratory support and maintenance such as assisting with preparing standard solutions, stocking and weekly inventory, and organizing incoming lab supplies. Performs other related duties as assigned by management. SUPERVISORY RESPONSIBILITIES: This job has...
Mar 15, 2023
Full time
Postdoctoral Fellow, Laboratory of Dr. Edward Callaway
Salk Institute for Biological Studies San Diego, CA, USA
The Callway Laboratory works with the billions of cells that make up the brain are a diverse bunch-some neurons are responsible for decision-making and others for memory, while some process information from the eye and others interpret smells. To understand how the brain organizes all these tasks and information, and what causes diseases like schizophrenia and autism, scientists need to map the connections between neurons. But it isn't easy, as the brain is more like a tangled bowl of spaghetti than a neat matrix of city streets. And techniques to look at the brain have mostly only allowed researchers to get a big-picture view of structure rather than to zoom in on individual cells. We are currently seeking a highly motivated and independent postdoctoral fellow to   study cell types and their connections in the cerebral cortex. To learn more about the lab, use the following link   https://www.salk.edu/scientist/edward-callaway/ Education:   Ph.D. in...
Mar 15, 2023
Full time
Education Outreach Manager
Salk Institute for Biological Studies San Diego, CA, USA
Oversee digital programming for community engagement programs, including SciChats@Salk and develop strategies to scale programs to a global scale. Oversee scientific literacy programs, work with Salk faculty on outreach projects, and ensure efficacy of all education programs. Supervise the two education outreach specialists. DUTIES AND RESPONSIBILITIES: Program scaling and digital learning strategies- Oversee SciChats@Salk. Work with the community engagement, communications, and scientific staff to develop digital learning programs. Develop strategies to deliver this programming on a national scale. Scientific Communications - Develop new programs including a scientific literacy program "Making Sense of Science" and build out partnerships and strategies to deliver this programming to regional community and beyond. Develop Community Science projects to engage the public with Salk research. Work with the Communications team to pilot and implement a...
Mar 15, 2023
Full time
Research Assistant I, Laboratory of Plant Biology, Dr. Wolfgang Busch
Salk Institute for Biological Studies San Diego, CA, USA
The CRoPS project aims to develop crop plants that sequester more carbon via extensive root systems containing recalcitrant carbon polymers to fight climate change. A major component of this research is to confirm trait changes through genetic manipulation and various phenotyping methods. The Research Assistant I will work closely with a Post doc, and other members of the CRoPS project and the Busch laboratory to conduct screening of root traits to identify genetic/molecular mechanisms that lead to optimal root systems for carbon sequestration. Responsibilities include plant maintenance and manipulation, plant transformation and transgenic plants selection, trait measurement, optimizing protocols for plant growth and plant measurements, confocal microscopy observation and image analysis, data analysis, and utilizing molecular biology techniques such as primer design, PCR, DNA/RNA extraction, bacterial transformation, and cloning to further characterize genes....
Mar 13, 2023
Full time
Postdoctoral Fellow - Residency Program in Laboratory Animal Medicine
Salk Institute for Biological Studies San Diego, CA, USA
Residency Program in Laboratory Animal Medicine at the Salk Institute for Biological Studies.  The Salk Institute Animal Resources Department (ARD) has one (1) position open for a Residency in Laboratory Animal Medicine (LAM) starting July/August 2023. The program is designed to prepare veterinarians for a career in LAM. The residency is approved by the American College of Laboratory Animal Medicine (ACLAM) and fulfills eligibility requirements for the ACLAM certifying examination. The resident will rotate within the ARD services and gain experience in the medical, surgical, anesthetic and behavioral management of a variety of laboratory animal models used at the Institute, including, but not limited to, mice, rats, rabbits, guinea pigs, naked mole rats and nonhuman primates. Residents will have the opportunity to spend time at collaborating institutions in San Diego and elsewhere to be exposed to other species. Residents will also participate in the...
Mar 09, 2023
Full time
Research Assistant II - Molecular Neurobiology Laboratory - Dr. Martyn Goulding
Salk Institute for Biological Studies San Diego, CA, USA
SUMMARY: The Research Assistant II position is responsible for preforming immunohistochemistry and assisting ongoing projects under moderate supervision with some latitude for independent judgement. Typically makes detailed observations. DUTIES AND RESPONSIBILITIES: Molecular Biology, Genetics, and Histology techniques in neuroscience. Mouse Colony Handling and Maintenance Lab Support  Performs other related duties as assigned by management. SUPERVISORY RESPONSIBILITIES: This job has no supervisory responsibilities. QUALIFICATIONS: Minimum 2 years' experience or equivalent combination of education and experience. Bachelor's degree in Biological Sciences or related STEM discipline required. Bachelor's degrees in a different discipline and a minimum of 4 years of experience in a scientific role will be considered in lieu. Demonstrated experience and application of molecular biology, genetics, and histology knowledge. Skills...
Mar 08, 2023
Full time
Core Research Specialist
Salk Institute for Biological Studies San Diego, CA, USA
 The Stem Core Research Specialist will perform moderately complex laboratory procedures related to the use of human stem cells and derivation of somatic cell populations for disease modeling applications. This position will primarily support human cell modeling needs associated with multiple research centers on campus, including centers focused on novel cell modeling approaches for aging and Alzheimer's disease. DUTIES AND RESPONSIBILITIES: Performs direct conversion and differentiation workflows to generate neural cell lineages as well as other cell types. Independently performs functional and characterization assays related to these cell types. Plays a primary role in the production and distribution of specified cell types and organoids to meet the needs of research groups and centers supported by the Stem Cell Core. Develops existing and new protocols pertaining to the use of human somatic and human pluripotent cell lines for research purposes....
Mar 07, 2023
Full time
Manager - Security Services
Salk Institute for Biological Studies San Diego, CA, USA
SUMMARY: The Manager, Security Services assists the Director, Security & Campus Services with day-to-day operations of 24x7 security shifts. Maintains overall security of the Institute campus and off-site locations, schedules, supervises, and trains security personnel, ensures opening and closing of the Institute at designated times, and responds to and investigates incidents and emergencies as dispatched or observed. DUTIES AND RESPONSIBILITIES: Scheduling of blended in-house, contract staff, and special events coverage, ensuring all shifts are covered and personnel are performing duties, in accordance with Post Orders, Standard Operating Procedures (SOP), and various regulatory requirements. Manages external security vendor and administers contract relationship, including ongoing informal feedback and monthly formal scorecard metrics. Conducts weekly security briefing during New Hire Orientation (NHO), various trainings, presentations, and...
Feb 27, 2023
Full time
Lab Administrative Mgr
Salk Institute for Biological Studies San Diego, CA, USA
Provides general administrative (executive level) support to the PI and affiliated lab group including lab management, grant writing, editing and general administrative assistance. Manage and administer program activities for Centers and large NIH grants. Uses initiative, resourcefulness and good judgment to handle a wide variety of administrative and support duties such as project management, addressing inquiries, maintaining filing systems, processing paperwork, composing correspondence and coordinating meetings and travel arrangements. Serves as liaison to administrative units (Payroll, Human Resources, IT, etc.). Works both independently and as a team member.  With limited guidance, prioritizes and executes responsibilities, applies experience & judgment to make decisions or resolve complex issues beyond the scope of defined standard protocols.  May provide some assistance/and or guidance to lower-ranked administrative support staff.     ESSENTIAL...
Feb 27, 2023
Full time
Senior Director, Development
Salk Institute for Biological Studies San Diego, CA, USA
Reporting to the Vice President for External Relations, the Senior Director for Development (SDD) is a critically important leadership role, primarily responsible as a member of the External Relations (ER) leadership team for building and mentoring a philanthropy team whose responsibility it is to identify and close gifts at the $100,000 and higher level in order to advance the mission of scientific discovery at the Salk Institute.  The SDD will help lead the completion of the current Campaign through their team's portfolio-based fundraising work, as well as to help position the Salk Institute for a future Campaign.            DUTIES AND RESPONSIBILITIES: Program Management: In consultation with the Vice President for External Relations, the SDD oversees a comprehensive stewardship and recognition program for major donors/prospects. The SDD has the responsibility for assigned events involving major donors and trustees and works with faculty, senior...
Feb 23, 2023
Full time
Research Assistant I - Molecular & Cell Biology Laboratory - Dr. Diana Hargreaves
Salk Institute for Biological Studies San Diego, CA, USA
Position available in the Hargreaves Lab for overall lab management duties in support of the Principal Investigator's (PI) studies. General lab maintenance duties include maintaining adequate inventory of materials and equipment to ensure adequate supplies for experimental needs, ordering supplies, taking inventory, upkeep and safety. Position is also responsible for performing various molecular biology, biochemistry, cell biology and mouse phenotyping techniques in support of lab and PI research goals. Range of duties include, but is not limited to: conducting procedures, modifying procedures as needed, data collection and analysis, tissue culture, recombinant DNA techniques, animal dissection, and laboratory maintenance. ESSENTIAL FUNCTIONS (30%) Molecular Biology Techniques Perform chromatin immunoprecipitation, RNA purification, next-generation library preparation, ATAC-seq, CUT&RUN, CUT&TAG, and RT-qPCR for the study of epigenetic...
Feb 22, 2023
Full time
Postdoctoral Fellow - Gene Expression Laboratory, Dr. Janelle Ayres
Salk Institute for Biological Studies San Diego, CA, USA
Our research employs cross-disciplinary approaches (genetics, transcriptomics, microbiology, immunology, physiology and metabolism) to understand host-microbe interactions in a diverse array of diseases including infectious diseases, inflammation and cancer. An ideal postdoctoral fellow candidate would have a demonstrated expertise in the following fields: Mouse models of infections, inflammation and cancer. We seek a candidate who has knowledge and experience with in vivo mouse models of infections, inflammation and cancer.  Immunology biology. We seek a candidate who is familiar with the field of immunology and that will be able to apply their conceptual and mechanistic understanding of immunology to our animal models. Metabolism. We seek a candidate who is familiar with the field of immunometabolism and metabolism in general and that will be able to apply their understanding to our animal models. Molecular and cell biology. We seek a candidate who...
Feb 13, 2023
Full time
Staff Researcher, Laboratory of Dr. Christian Metallo
Salk Institute for Biological Studies San Diego, CA, USA
The Staff Researcher will perform mass spectrometry-based metabolomics and lipidomics to understand the mechanistic drivers of neurological disorders and cancer associated with dysregulated amino acid metabolism. These studies will involve targeted analytics of clinical samples, animal tissues, and organoid models as well as metabolic flux studies using stable isotope tracers (e.g. 13C, 15N, 2H). The Staff Researcher will execute these analyses with the support of scientists in the Metallo lab and interact with collaborating scientists and clinicians to advance our understanding of metabolic dysfunction in cancer, macular telangiectasia, and neurodegenerative disorders. The successful applicant will design innovative analytical strategies for patient diagnosis and mechanistic interventions for cancer and neurodegenerative disorders associated with metabolic dysfunction, working as part of a dynamic and multi-disciplinary team to study mammalian physiology via...
Feb 06, 2023
Full time
Senior Director, Stewardship
Salk Institute for Biological Studies San Diego, CA, USA
  Job location  is at  10240 Science Center Dr,  San Diego, CA 92121 The Senior Director for Stewardship is a leadership position at the Salk Institute on the External Relations (ER) team.  The Senior Director is responsible for all Stewardship activities, including: prioritization of data integrity and CRM management and oversight; data analytics and donor portfolio management; metrics management; data-driven donor research and analytics; strategic programming management and oversight; alumni programming and related strategy; donor and endowment data analysis and related reporting; generation, analysis and management of various reports using enterprise systems; management of the Stewardship team; and close coordination with fellow Senior Directors and Directors on the ER team.  The Senior Director performs a critical important role in the daily management of the care of donor relationships at the Salk Institute. ESSENTIAL FUNCTIONS...