Salk Institute for Biological Studies

  Job #: G939 Posted Date: January 14, 2020 Closes On: Open Until Filled Job Title: Veterinary Tech II Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Animal Resources The ARD is dedicated to providing the highest quality of veterinary medical care, husbandry, enrichment and professional technical support to enable the scientists and their research. Position Description: The position is expected to practice approved veterinary technical skills autonomously with or without constant/direct supervision on behalf of the attending veterinarian to ensure the health and wellbeing of research animals in accordance with all federal, state and institutional laws, regulations, policies and guidelines and based on departmental programmatic needs. The incumbent is expected to work actively with USDA covered species, including non-human primates (NHP). The position is also expected to assume a leading role in providing highly skilled technical support to research programs, and in training of animal users and less-experienced animal care technicians at the Institute. Education: Required: Graduation from AVMA or State of California approved animal health technician program. RVT (or CVT/LVT) and LATG certification or ability to obtain certification within 6 months of hire into position. Preferred: VTS-Laboratory animal medicine specialty certification. Experience: Required: Minimum 5 years of relevant experience in a laboratory animal facility or research facility with specific pathogen free (SPF) rodents, rabbits, guinea pigs, non-human primates, and other laboratory animals, of which up to 2 years of experience may be obtained through completion of veterinary technician schooling. The 5 or more years of overall experience must also include a minimum of 3 years of training experience in laboratory animal science and 3 years of clinical veterinary experience, which may be obtained concurrently. Extensive hands-on experience with animal husbandry, handling and restraint, blood sampling, injections, administering medications. Special Requirements: Must be willing to work in an animal-related research environment. Successful completion of the Institute’s background investigation. Able to work a flexible schedule based on workload and deadlines. Must be able to work assigned schedule of 6:30 a.m. - 3:00 p.m. with any of these shifts; Monday – Friday/ Sunday-Thursday/ Tuesday-Saturday or Wednesday-Sunday. Must be able to work overtime as needed before or after regular shift or on weekends. Post offer physical required which may include respirator fit test. Emergency on-call duties may be required. Willing to sign an employee confidentiality agreement. OCCUPATIONAL HEALTH & SAFETY PROGRAM REQUIREMENTS As a safeguard for employees and animals, all ARD employees may be subject to vaccines/tests/physical exams prior to working with specific animals or animal populations as required by research needs including but not limited to: TB Testing/Clearance (every 12 months / once a year) Hepatitis B (proof of immunization and/or vaccination) Tetanus (vaccination < 10 years) Diphtheria (proof of immunization and/or vaccination) Measles (proof of immunization and/or vaccination) Periodic physical exams (may include respirator fit test) Other vaccines/tests as required by Occupational Health & Safety standards Physical Requirements: This position requires constant grasping, handling, hearing, keying, seeing, sitting, talking, touching, feeling and walking. Calculating, communicating, reading, writing, exposure to animals, fumes, odors, mists, dusts, potential allergens and working inside.  

  Job #: G941 Posted Date: January 9, 2020 Closes On: Open Until Filled Job Title: Postdoctoral Fellow - Integrative Biology Laboratory, Dr. Graham McVicker Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Integrative Biology Laboratory The McVicker laboratory studies how human genetic variation affects gene regulation by combining experimental approaches with computational analyses. We are especially interested in identifying pathogenic regulatory variants that act in immune cells and cancer cells. Currently, we are developing new tools to discover somatic regulatory mutations in cancer genomes, and manipulating cell lines with high-throughput CRISPR technologies to discover new regulatory sequences. In much of our research, we develop sophisticated computational and statistical methods so that we can extract subtle signals from noisy experimental data. Position Description: Quantitative trait mapping of single cell gene expression and chromatin traits The McVicker Laboratory at the Salk Institute for Biological Studies is seeking a postdoctoral fellow to tackle cutting-edge research problems in genetics, gene regulation and chromatin biology. The successful candidate will develop new statistical and computational methods to map single cell gene expression and chromatin traits and will have the opportunity analyze large single-cell ATAC-seq and single-cell RNA-seq datasets. These datasets are being collected by our collaborators at UCSD, and will be used to better understand the genetic basis of complex diseases including opioid addiction and type 1 diabetes. Diversity: We are committed to diversity in science. The Salk Institute for Biological Studies is an Equal Opportunity Employer. Location The Salk Institute for Biological Studies is an architectural landmark and is one of the top biological research institutes in the world. It is located in beautiful La Jolla, a community of San Diego, California, and is close to many biotechnology companies and other research institutes including the University of California, San Diego. Education: Applicants should have a strong quantitative background and must have, or expect to receive, a Ph.D. in a relevant discipline (Genetics, Computer Science, Statistics, Bioinformatics, etc.). Experience: Required skills/experience: Experience with Python or other scripting language Experience in R or other data analysis language Experience in statistics and/or machine learning Proficiency in Unix / Linux Proficiency in scientific writing and communication Contributions to published papers/preprints Strong interest in biology, chromatin, and gene regulation Desired skills/experience: Experience with bioinformatics tools / software Experience with next-generation sequencing data Experience with single-cell genomics Experience with C/C++ or other compiled programming language Ability to work closely with collaborators from diverse backgrounds Interest in complex human traits, especially diabetes or addiction, using human samples and animal models of disease Application Instructions: Email Dr. Graham McVicker at gmcvicker@salk.edu with your CV, a brief cover letter describing your background and research interests, and contact information for 2-3 references.  

  Job #: G942 Posted Date: January 10, 2020 Closes On: January 24, 2020 Job Title: Lab Tech II - Molecular and Cell Biology Laboratory, Dr. Tony Hunter Status: Temporary Part Time Benefits Eligible: No Laboratory/Department: Molecular and Cell Biology Laboratory Laboratory studies how cells regulate their growth and division, and how mutations in genes that regulate growth lead to cancer. Current efforts are aimed at elucidating how protein phosphorylation, ubiquitination, and SUMOylation events are used to regulate cell proliferation and growth control, and cell cycle checkpoint activation in response to DNA damage. Position Description: This person will assist with lab support (solution making and autoclaving), and will be trained to perform basic biochemical techniques including gel electrophoresis, (both protein and DNA); immunofluorescence; plasmid preparation; mammalian cell culture; mouse handling and colony management; and PCR used to make mutant proteins and to genotype mice. Education: Required: Undergraduate degree and coursework in biological sciences or related fields, or equivalent combination of education or experience. Preferred: Bachelor’s degree with emphasis in biological sciences. Experience: Required: 6 months experience as a lab technician or equivalent related experience. Special Requirements: Must be willing to work in an animal-related research environment. Must be willing to work an adjusted schedule to support research needs. Successful completion of the Institute’s background investigation. Must be willing sign a confidentiality agreement. Physical Requirements: This position requires constant adjusting focus, grasping, hearing, keying, seeing, talking, analyzing, calculating, communicating, reading, reasoning, writing, working inside and in confined areas.  

  Job #: G945 Posted Date: January 13, 2020 Closes On: Open Until Filled Job Title: Research Assistant II/III - Molecular Neurobiology Laboratory, Dr. Nicola Allen Status: Regular Full Time Benefits Eligible: Yes Position Description: Position is responsible for assisting two projects investigating non-neuronal brain cells called astrocytes: 1) development of astrocytes; 2) how astrocytes affect the progression of neurodegenerative disorders. Duties include harvesting brain tissue, processing brain tissue for analysis, tissue sectioning, immunohistochemistry, confocal microscope imaging, molecular biology including cloning and analysis of RNA. Must be able to work independently after the initial training period. Education: Required: Bachelor’s degree in the biological sciences, preferably neuroscience component. Experience: Required: Immunohistochemical analysis of brain tissue. Molecular biology including knowledge of cloning. Microscopy Mouse handling. Preferred: Familiarity with sequencing technologies. Special Requirements: Must be willing to work in an animal-related research environment. Satisfactory completion of the Institute’s background investigation. Willing to work an adjusted schedule when research needs require it. Must be willing to sign a confidentiality agreement. Physical Requirements: This position requires constant adjusting focus, grasping, hearing, seeing and talking.  

  Job #: G947 Posted Date: January 15, 2020 Closes On: January 28, 2020 Job Title: Project Scientist - Gene Expression Laboratory, Dr. Geoffrey Wahl Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Gene Expression Laboratory The research focuses on two important problems related to cancer biology. Currently, the studies revolve around the mammary gland to determine whether breast cancer arises from mutations within the stem cells that generate this tissue. The long-term goal of these studies is to determine whether such cells exhibit growth requirements and patterns of drug sensitivity that might be targeted for the development of more effective therapeutics. Position Description: The Project Scientist is expected to make significant contributions to a research project focused on important problems related to cancer initiation, detection, progression, metastasis and treatment. The Project Scientist will work independently in a support role under the general guidance of a PI. Goals or objectives of projects are set by PI and are accomplished within prescribed time frame and funding parameters that include molecular cloning, protein purification, diverse methods of RNA and protein analysis, tissue culture and selection of variants after transfection, and inducible expression systems. This position is expected to establish work plan and staffing for each phase of project and demonstrate success in a technical field. A Project Scientist is also responsible for overseeing the scientific progress of an assigned project, including setting priorities, planning procedures, coordinating activities of team members, allocating/securing resources and equipment, recording, integrating and reporting results of project phases and team, training team members and determining flow of activities between departments. The Project Scientist will be part of our ongoing mission to devise novel strategies to intercept cells undergoing reprogramming to reduce the probability that drug resistant or metastatic clones will arise or spread. Education: Required: PhD or MD degree in Biological Sciences, computational biology or related fields, or equivalent experience. Experience: Required: Minimum of 3 years of related post PhD/MD experience or equivalent. Special Requirements: Must be willing to work in an animal-related research environment. Satisfactory completion of the Institute’s background investigation. Willing to sign a confidentiality agreement. Physical Requirements: This position requires constant adjusting focus, handling, hearing, keying, seeing, sitting, talking, analyzing, calculating, communicating, reading, reasoning, writing, working in confined areas and inside.  

  Job #: G941 Posted Date: January 9, 2020 Closes On: Open Until Filled Job Title: Postdoctoral Fellow - Integrative Biology Laboratory, Dr. Graham McVicker Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Integrative Biology Laboratory The McVicker laboratory studies how human genetic variation affects gene regulation by combining experimental approaches with computational analyses. We are especially interested in identifying pathogenic regulatory variants that act in immune cells and cancer cells. Currently, we are developing new tools to discover somatic regulatory mutations in cancer genomes, and manipulating cell lines with high-throughput CRISPR technologies to discover new regulatory sequences. In much of our research, we develop sophisticated computational and statistical methods so that we can extract subtle signals from noisy experimental data. Position Description: Quantitative trait mapping of single cell gene expression and chromatin traits The McVicker Laboratory at the Salk Institute for Biological Studies is seeking a postdoctoral fellow to tackle cutting-edge research problems in genetics, gene regulation and chromatin biology. The successful candidate will develop new statistical and computational methods to map single cell gene expression and chromatin traits and will have the opportunity analyze large single-cell ATAC-seq and single-cell RNA-seq datasets. These datasets are being collected by our collaborators at UCSD, and will be used to better understand the genetic basis of complex diseases including opioid addiction and type 1 diabetes. Diversity: We are committed to diversity in science. The Salk Institute for Biological Studies is an Equal Opportunity Employer. Location The Salk Institute for Biological Studies is an architectural landmark and is one of the top biological research institutes in the world. It is located in beautiful La Jolla, a community of San Diego, California, and is close to many biotechnology companies and other research institutes including the University of California, San Diego. Education: Applicants should have a strong quantitative background and must have, or expect to receive, a Ph.D. in a relevant discipline (Genetics, Computer Science, Statistics, Bioinformatics, etc.). Experience: Required skills/experience: Experience with Python or other scripting language Experience in R or other data analysis language Experience in statistics and/or machine learning Proficiency in Unix / Linux Proficiency in scientific writing and communication Contributions to published papers/preprints Strong interest in biology, chromatin, and gene regulation Desired skills/experience: Experience with bioinformatics tools / software Experience with next-generation sequencing data Experience with single-cell genomics Experience with C/C++ or other compiled programming language Ability to work closely with collaborators from diverse backgrounds Interest in complex human traits, especially diabetes or addiction, using human samples and animal models of disease Application Instructions: Email Dr. Graham McVicker at gmcvicker@salk.edu with your CV, a brief cover letter describing your background and research interests, and contact information for 2-3 references.

  Job #: G805 Posted Date: January 8, 2020 Closes On: Open Until Filled Job Title: Animal Health Technician I Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Animal Resources The ARD is dedicated to providing the highest quality of veterinary medical care, husbandry, enrichment and professional technical support to enable the scientists and their research. Position Description: This position is responsible for routine processing of clean and soiled cages and accessories, maintenance and general janitorial duties in animal facilities, equipment maintenance, basic QA testing, processing deliveries from vendors and performing basic rodent husbandry tasks based on standard operating procedures and training to ensure compliance with the Guide for the Care and Use of Laboratory Animals, the Animal Welfare Act and Regulations as well as all applicable federal, state, local and institutional laws, regulations, policies and guidelines. Education: Required: High school diploma or equivalent (AHT 1 LEVELS A/B/C) Preferred: AALAS certification at ALAT or higher level (AHT1 LEVEL C) A.A, B.A or B.S. degree. Experience: Required: AHT 1, LEVEL A: No experience necessary AHT 1, LEVELS B/C: Minimum 1 year of relevant work experience. Special Requirements: Must be able to work a flexible schedule that may include weekends and holidays. Must be able to work overtime based on workload and deadlines. Must be able to work assigned standard schedule: Monday – Friday, Sunday - Thursday, Tuesday - Saturday from 6:00 a.m.- 2:30 p.m./6:30 a.m. - 3:00 p.m./7:00 a.m. - 3:30 p.m./ 8:00 a.m.- 4:30 p.m. Management reserves the right to change or modify assigned schedules based on operational needs. Post offer physical required which may include respirator fit test. Possible rotating schedule. OCCUPATIONAL HEALTH & SAFETY PROGRAM REQUIREMENTS As a safeguard for employees and animals, all ARD employees may be subject to vaccines/tests/physical exams prior to working with specific animals or animal populations as required by research needs including but not limited to: TB Testing/Clearance (once a year) Tetanus/ Diphtheria (vaccination < 10 years proof of immunization and/or vaccination) Measles (proof of immunization and/or vaccination) Periodic physical exams (may include respirator fit test) Other vaccines/tests as required by Occupational Health & Safety standards Physical Requirements: This position requires constant standing, seeing, adjusting focus, grasping, hearing, handling, lifting 0-20 pounds, communicating, being exposed to noise, potential allergens, fumes/odors/mites/ dust and working inside.  

  Job #: G344 Posted Date: January 3, 2019 Closes On: Open Until Filled Job Title: Postdoctoral Position - Systems Neurobiology Laboratory, Dr. John Reynolds Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Systems Neurobiology Laboratory The long-range goal of the laboratory is to understand the neural mechanisms of selective visual attention at the level of the individual neuron and the cortical circuit, and to relate these to perception and conscious awareness. Position Description: A postdoctoral position funded by the NIH is immediately available in the laboratory of Professor John Reynolds at the Salk Institute. The postdoctoral fellow will work with Dr. Reynolds on a collaborative project involving experimentalists (Reynolds and Mark Histed, NIH) and theoreticians (Ken Miller, Columbia University; Nicolas Brunel, Duke) in which we will combine optogenetics, computational modeling, multi-electrode electrophysiology, and visual psychophysics in behaving mice and non-human primates to pursue research questions concerning the relationship between neural activity and visual perception. The position is fully funded for two years, with the potential for extending funding upon successful completion of initial project goals. Education: PhD in related field Application Instructions: Applicants should send their CV and contact details of two referees to Sally Ganley sganley@salk.edu . Overlooking the Pacific Ocean, the Salk Institute offers a warm, collegial and collaborative work environment. The Institute consistently ranks among the leading research institutions in the world for its faculty's contributions and the impact of their findings. The Institute has trained more than 2,000 scientists, many of whom have gone on to positions of leadership in other prominent research centers worldwide. The Institute is committed to the principles and practices of equal employment opportunity. It is our policy to provide equal employment opportunities to all employees and applicants for employment without regard to unlawful considerations of race, religion, color, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, marital status, genetic information, status as a disabled veteran, veteran of the Vietnam era, other covered veteran, or any other classification protected by applicable local, state, or federal laws. Reasonable accommodation is available for qualified individuals with disabilities.  

  Job #: G843 Posted Date: January 7, 2020 Closes On: Open Until Filled Job Title: Accountant III Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Finance The Finance department provides a broad range of financial and accounting services to both faculty and administration. Position Description: Works independently in performing the duties of the position, under the general direction of the Assistant Controller. Responsibilities may include: Preparing and analyzing monthly and annual reconciliations for multiple funds and accounts. Participating in the monthly close reconciliation and financial reporting process. Preparing and analyzing schedules for the Form 990 tax reporting and the annual indirect cost proposal. Preparing HHMI invoices, journals, and reconciliation for accounts receivable. Maintaining accounting records and preparing federal/state tax returns for SICSC. Analyzing data and preparing annual Form 1099's and 592-B's. Preparing and analyzing year-end audit schedules. Preparing monthly sales tax reports. Reviewing coding of contributions and preparing monthly reconciliation of contributions recorded by Finance with Development's reports. Maintaining fixed assets system and conducting inventory. Processing and analyzing monthly recharges from core facilities and other shared service departments. Maintaining, analyzing, and reconciling accounts receivable (internal and external). Processing, depositing, and journalizing cash receipts. Ensures confidentiality of information, follows accounting principles, and exercises sound judgment. Education: Required: Bachelor's degree in Accounting, Business or related field, or equivalent combination of education and related work experience in accounting, payroll or finance. Experience: Required: Minimum of five years of professional experience in accounting or finance. Must have the ability to interpret reports and analyze data with attention to detail. Must have strong problem-solving skills including the ability to recommend options and implement solutions. Preferred: Experience with Ellucian Banner finance system Leadership experience. Special Requirements: Must be willing to work in an animal-related research environment. Must be able to work overtime as needed and occasionally work a flexible schedule based on workload and deadlines. Peak times include month-end and year-end close, and audits. Must be willing to work at a location away from the main campus (but within walking distance) and travel to and from campus as needed (parking is available at both locations). Successful completion of the Institute’s background investigation. Willing to sign an employee confidentiality agreement. Physical Requirements: This position requires constant adjusting focus, grasping, seeing, touching/feeling, and handling.  

  Job #: G826 Posted Date: January 8, 2020 Closes On: Open Until Filled Job Title: Senior Systems Engineer Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Information Technology The IT department operates and maintains the Institute's core network / compute / storage infrastructure and provides engineering and operational support services to labs and administrative departments. Position Description: Under general direction and reporting to the Information Technology Manager, provides systems engineering and operational management of technology infrastructure supporting data and compute-intensive research laboratories. Additionally, provides engineering and operational support for administrative systems and core technology services. Position requires research, design, planning, installation, configuration, operation and maintenance of complex infrastructure platforms requiring a high degree of technical knowledge and systems integration experience. Position assists with specification, procurement, installation and testing of physical and virtual server configurations. Position requires ongoing support for complex systems and applications, as well as providing advanced-level technical support for end users in both labs and administrative departments. Incumbent will support several mission-critical Information Technology systems services, and will manage high-performance computational and storage systems used by labs. Position requires participation in an on-call rotation to provide critical 24x7 coverage. The Senior Systems Engineer is challenged with establishing and maintaining a high level of credibility and quality for services provided by the Information Technology department. In meeting these goals, the Senior System Engineer constantly evaluates the state of the art in Information Technology and applies creative solutions to satisfy research and business needs in support of the Institute’s mission. The Salk Institute is a world renowned private, non-profit biological research organization. Come join our team and enjoy a low-stress environment with a great work/life balance. Take advantage of flexible work schedules and great benefits. Education: Required: BS or BA in computer science or a related technical field or equivalent combination of education and experience. Experience: Required: Minimum of seven years experience managing enterprise-class compute and storage hardware, including SAN and NAS solutions. Minimum of seven years of UNIX operating systems administration experience in an enterprise client-server environment. Experience managing a virtualization platform infrastructure in an enterprise environment. Experience engineering and implementing complex solutions that require knowledge in multiple domains of information technology. Preferred: Ten years experience managing enterprise-class compute and storage hardware. Five years managing RHEL / CentOS workloads in large client-server enterprise environment. Five years engineering / implementing complex IT solutions. Five years managing VMware ESXi and vSphere virtualization platforms. Experience with cloud storage and computer platforms. Special Requirements: Must be willing to work in an animal-related research environment. Satisfactory completion of the Institute’s background investigation. Willing to sign a confidentiality agreement. Physical Requirements: This position requires constant grasping, hearing, keying, seeing, talking, analyzing, communicating, reading, reasoning, writing and working inside.  

Job #: E467 Posted Date: April 22, 2016 Closes On: Open Until Filled Job Title: Research Associate - Center for Integrative Biology, Dr. Saket Navlakha Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Integrative Biology Laboratory With new emerging technologies, biologists are producing massive amounts of data that could unveil the rules that govern complex biological processes and how these processes are disrupted by diseases. The Integrative Biology Laboratory is interested in developing new algorithmic and computational methods to decipher this data and help inform future experiments. Position Description: A post-doc position in Dr. Navlakha's lab in the Center for Integrative Biology is available immediately. We are looking for highly motivated computational post-docs interested in molecular and cellular network analysis (network robustness, evolution, development, etc.); algorithms in nature (information processing and computation in biological systems); and bioimage informatics. We typically develop combinatorial (graph-based) or machine learning algorithms to address important biological questions. Working at The Salk Institute provides a unique opportunity for computational scientists to integrate theory and experiment to bear on deep and complex scientific questions. Overlooking the Pacific Ocean, the Salk Institute offers a warm, collegial and collaborative work environment, with UCSD also right across the street. Education: PhD in computer science or related field. Experience: Strong algorithmic and programming skills, publications in top conferences or journals, experience in computational systems biology. Application Instructions: Applicants should send curriculum vitae, contact information for three references to: Dr. Saket Navlakha Email: navlakha@salk.edu

  Job #: G876 Posted Date: December 17, 2019 Closes On: Open Until Filled Job Title: Animal Health Tech II Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Animal Resources The ARD is dedicated to providing the highest quality of veterinary medical care, husbandry, enrichment and professional technical support to enable the scientists and their research. Position Description: This position is responsible for the basic daily husbandry operations in all facilities and with all species in accordance with standard operating procedures and training to ensure compliance with the Guide for the Care and Use of Laboratory Animals, the Animal Welfare Act and Regulations as well as all applicable federal, state, local and institutional laws, regulations, policies. Education: Required: High school diploma or equivalent. ALAT certification by AALAS or equivalent. Preferred: LAT certification by AALAS. A.A, B.A or B.S. degree. Experience: Required: Minimum 3 years of relevant work experience. Special Requirements: Must be able to work a flexible schedule that may include weekends and holidays. Must be able to work overtime based on workload and deadlines. Must be able to work assigned standard schedule: Monday – Friday, Sunday - Thursday or Tuesday - Saturday, 6:00 a.m.- 2:30 p.m./6:30 a.m. - 3:00 p.m./7:00 a.m. - 3:30 p.m./ 8:00 a.m.- 4:30 p.m. Post offer physical required which may include respirator fit test. Possible rotating schedule. OCCUPATIONAL HEALTH & SAFETY PROGRAM REQUIREMENTS: As a safeguard for employees and animals, all ARD employees may be subject to vaccines/tests/physical exams prior to working with specific animals or animal populations as required by research needs including but not limited to: TB Testing/Clearance (once a year) Tetanus/ Diphtheria (vaccination < 10 years proof of immunization and/or vaccination) Measles (proof of immunization and/or vaccination) Periodic physical exams (may include respirator fit test) Other vaccines/tests as required by Occupational Health & Safety standards Physical Requirements: This position requires constant standing, hearing, working inside, exposure to fumes/odors/mists/dusts, animals and potential allergens.  

Job #: G827 Posted Date: December 17, 2019 Closes On: Open Until Filled Job Title: Vice President, Innovation & Commercialization Status: Regular Full Time Benefits Eligible: Yes Special Instructions: No submissions from search firms/agencies/consultants for this position will be accepted. Position Description: Reporting to the President, the Vice President (VP), Innovation & Commercialization will be responsible for facilitating Salk’s foundational biological science research mission by providing vision and leadership in efforts to advance, disseminate and commercialize Salk discoveries through the formation of strategic partnerships, collaborations and Institute-wide alliances. The ideal incumbent will have broad generalist knowledge and experience that allows for orthogonal innovation pathways to take basic discoveries into various application domains. Ideally these would span across biology, molecular, cell and organ/physiology levels, ecosystems, quantitative methods in sensing, imaging, actuation, design, quality control, medicinal chemistry, regulatory matters and international variations, technology or engineering for diagnostics and POC devices, disposables, computational and pharmacokinetic/pharmacodynamic modeling, etc. The VP will have executive or senior-level leadership experience in pharma, biotech or a similar industry, experience in academia, and a proven track record of identifying and closing successful business transactions. The executive will demonstrate an understanding of, a genuine passion for, and the ability to compellingly translate the Institute’s complex, cutting-edge biomedical research to a broad range of audiences. The VP must be a collaborative, innovative, imaginative and creative deal-maker with an entrepreneurial spirit, well-connected, and a tenacious self-starter with the ability to plan and act strategically. At all times, it is incumbent upon the VP to align all of their actions with the Salk mission and represent that alignment to external constituents. In doing so, this VP will remain cognizant that while revenue is a goal, scientific discovery is the core mission, which will be key to structuring transactions and making decisions involving intellectual property. Through well-defined initiatives and effective partnerships, this role presents an opportunity to design and deliver a transformative and strategic function that values and supports principles that are consistent across the organization in support of Salk’s mission to explore the very foundations of life through scientific discovery for the benefit of all. Facilitating the translation and commercialization of Salk discoveries enables people to avail themselves of this benefit. Please click https://www.salk.edu/wp-content/uploads/2019/10-VP-Innovatoin-Commercialization_10.01.19.pdf for a full job description Salk provides a competitive compensation and benefits package. Education: Required: MS in Life Sciences Preferred: MBA, PhD in Life Sciences or JD Experience: Required: 15+ years of increasingly responsible and successful leadership experience in academia and/or therapeutic or diagnostic product development, marketing and/or business development in the biotechnology, life science or pharmaceutical industry. Individuals with fewer years of experience may qualify if they have exceptional leadership skills and a demonstrated track record of contributions that have had significant organizational impact. Deal sheet that demonstrates the ability to analyze and optimize deal structures and terms to successfully deliver returns that result in sustained profitability. Experience developing and maintaining domestic and global connections and direct contacts in life sciences, venture capital firms, the broader investment community and other organizations that would add value to this role. Extensive experience shaping and leading corporate transactions, preferably with focus on strategic collaborations, including negotiating, drafting, reviewing, revising and closing a variety of sophisticated and complex transactions Track record of successes in establishing and maintaining harmonious, productive relationships (both internal and external), managing through ambiguity and obstacles with confidence and optimism, seeing them as opportunities to bridge the gap between scientific innovation and translation Experience with “nuts and bolts” of intellectual property and technology transfer: invention disclosures, patent filings and maintenance, patent portfolio strategy for each technology and/or lab group, smart use of external domain experts, material transfer agreements (MTAs), contract terms approval, license terms and negotiations, start-up formation, cap tables, and mentoring staff in business development and commercialization Experience in managing a moderately-sized staff with multi-functional roles, managing large and complex budgets, assessing outcomes. Experience structuring transactions with not-for-profit, basic research or academic institutions. Preferred: Experience performing academic or commercial research and development. Special Requirements: Must be resident (or willing to reside) in the greater San Diego area. Must be able to travel as needed to support the role. Must be willing to work in an animal-related research environment. Successful completion of the Institute’s background investigation. Physical Requirements: This position requires constant adjusting focus, grasping, keying, hearing, seeing, sitting, talking, analyzing, calculating, communicating, reading, reasoning, writing and working inside.

Job #: G634 Posted Date: June 18, 2019 Closes On: Open Until Filled Job Title: Postdoctoral Fellow - Waitt Advanced Biophotonics Center & Molecular and Cell Biology Laboratory Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Waitt Advanced Biophotonics Center & Molecular and Cell Biology Laboratory Position Description: Postdoctoral Position for Imaging Mitochondria in Disease Models The Waitt Advanced Biophotonics Center has been established at the Salk Institute for Biological Studies as a state-of-the-art research hub to provide advanced and emerging imaging modalities to enable unprecedented insights into the inner workings of cells, tissues and organisms. In collaboration with the Shadel Laboratory, a world leader in aging in health and disease, we are seeking a highly motivated and experienced postdoctoral candidate to develop novel transgenic, imaging, and gene therapy approaches to study inner ear hair cells and hearing restoration in deaf animal model systems. Education: PhD in related field Application Instructions: Send a short description of research interest and CV to umanor@salk.edu and gshadel@salk.edu .

Job #: F672 Posted Date: July 18, 2017 Closes On: Open Until Filled Job Title: Research Associate - Vision Center Laboratory, Dr. Thomas Albright Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Vision Center Laboratory Nearly every facet of human experience is colored by the sense of sight. The effortlessness and immediacy with which this sense conveys physical, social, and aesthetic qualities of one's environment belie the extraordinary complexity of the brain mechanisms involved. Our acute dependence upon these mechanisms is brought to the fore, however, by a variety of developmental, traumatic, and disease-related disorders of visual perception and visually-guided behavior. While rarely life- threatening, such disorders can be profoundly debilitating, impairing activities that we have come to take for granted, such as reading, driving, or recognizing family and friends. We seek a thorough understanding of brain mechanisms of visual information processing, with the promise of effective treatment and remediation of disorders of vision, as well as insights into the nature of our conscious experience of the world. The specific aims of our research have been to identify how sensory signals in the brain become "integrated" to form neuronal representations of the objects that populate our visual environment and form our conscious experiences of the world. To achieve this goal, we monitor both perceptual and neuronal events elicited by specific visual inputs. The results of these experiments enable us to infer the neuronal events that give rise to specific perceptual states, and they provide evidence for the neuronal circuitry that underlies sensory and perceptual representations in the brain. Position Description: A postdoctoral position funded by the NIH is immediately available at the Center for Neurobiology of Vision at the Salk Institute for Biological Studies in San Diego, California. The postdoctoral fellow will be working with Dr. Thomas D. Albright and Dr. Sergei Gepshtein who combine expertise in single-cell physiology in awake non-human primates, sensory psychophysics, and mathematical modeling of sensory mechanisms and perceptual behavior. The postdoctoral fellow will be invited to combine these methodologies, and pursue research questions concerning adaptive encoding of sensory information, perceptual organization, and psychophysical scaling. Education: Ph.D. is required. Experience: Strong computational skills are preferred Application Instructions: Email Cindy Doane at doane@salk.edu a cover letter describing your background and research interests, your CV, and contact information for 2-3 references. Contact Information: Thomas Albright, Ph.D. Vision Center Laboratory Salk Institute for Biological Studies 10010 N Torrey Pines Rd La Jolla, CA 92037 Albright Laboratory Website

  Job #: G820 Posted Date: December 17, 2019 Closes On: Open Until Filled Job Title: Grants Development Application Administrator Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Research Development Research Development provides pre-application services to faculty and staff seeking outside sources of funding for their research. The department helps investigators identify appropriate avenues for research support, with primary focus on developing and coordinating multi-investigator research programs. Position Description: The GRDEV Application Administrator is a creative, resourceful and integrative thinker responsible for the administration and day-to-day use of the GRDEV applications, as well as the development and implementation of new reporting and business intelligence tools. This role serves as the GRDEV technical point-of-contact and assists subject matter experts ensuring data integrity, testing of system changes, and analyzing data flows for process improvement opportunities. This position will require the development of a strong understanding of Grants Administration and Research Development data. This position implements and provides feedback into the vision and strategic objectives set by management to automate and streamline Grants Development (GRDEV) processes and proactively grow GRDEV application services while providing measurable value to department and Institute customers. Partners and collaborates with leaders and team members in GRDEV and across the Institute to analyze work process design and flow, systems gaps and problems, and manual inefficiencies. Collaborates with team members to improve processes and leverages the return on technological capabilities using best practices. Continually works to ensure that GRDEV and other Institute user needs are met in a manner that is effective and efficient. Position supports, in collaboration with Information Systems and relevant vendors, GRDEV application upgrades, patches, and testing. Participates in cross-functional support groups with Information Systems and other departments to coordinate system and process changes due to system maintenance (e.g. new software versions, new hardware), and administrative functions (e.g. creating new departments, addressing audit requirements). Documents system use and configuration changes. Proactively interfaces with end users and pertinent stakeholders to gather feedback and assist with projects. Proactively identifies opportunities for and suggests new COTS and custom applications to meet emerging data, analytics, and reporting needs. Develops requirements and prototypes for new applications. Education: Required: Bachelor’s Degree in Business, Computer Science, Information Systems, or equivalent years of relevant experience in a related field Experience: Required: 6+ years of progressive and professional experience in application management. 4+ years of experience with new systems requirement development and implementation. 3+ years of experience with analytics and business intelligence applications. Preferred: Knowledge of Cayuse SP and 424. Experience with Crystal Reports, Cayuse Reports, Power BI and PowerApps development. Knowledge of pre-award or post-award grants administration or related processes. Knowledge of NIH, NSF and DOD grants processes Project Management Professional (PMP). Special Requirements: Must be willing to work in an animal-related research environment. Satisfactory completion of the Institute’s background investigation. Physical Requirements: This position requires constant adjusting focus, hearing, keying, seeing, sitting, talking, analyzing, communicating, reading, reasoning, writing and working inside.  

Job #: F496 Posted Date: February 23, 2017 Closes On: Open Until Filled Job Title: Research Associate/Postdoctoral Scientist - Translational Research (Immunology/Oncology) Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Molecular and Cell Biology Laboratory Laboratory employs the help of a small DNA virus, called adenovirus, to both understand and treat cancer. DNA viruses and tumor cells sabotage such controls to drive their respective pathological propagation, albeit with one small difference: In tumor cells the key cellular players are targeted via mutations, while in infected cells viral proteins achieve the same end. Not surprisingly, many of the cellular targets are the same. Dr. O'Shea's lab is exploiting this overlap to help address three key questions: What are the critical cellular targets and pathways that drive deregulated growth? What is the human growth deregulation program and how do we uncouple it for tumor therapy? Can we manipulate viruses as novel therapeutic agents that trigger the rapid lytic death of tumor cells but leave normal cells unharmed? Position Description: The Salk Institute of Biological Studies is seeking an experienced Immunologist/ Oncologist to join a Translational Group with the responsibility of developing a new pipeline of virus-based therapeutics delivering immune modulatory payloads for the treatment of cancer. This is a “hands-on” scientist role focused on translational research that is well suited for postdoctoral scientists potentially interested in a transition to a biotech/industry setting. The successful candidate is expected to have a strong scientific background in immunology/oncology. Major activities will include: Conceive and design new immune-stimulatory therapeutics using novel platform technology Develop and execute in vitro assays to evaluate virus candidates for potency and immune activity. Design and execute in vivo studies to evaluate efficacy of therapeutic virus candidates in cancer disease models. Document, analyze, interpret and present results within a multi-disciplinary team environment. Work closely with the research group, CRO’s and external collaborators. Education: Candidate should have a Ph.D. in Immunology/Oncology or related field. Experience: Deep knowledge/expertise in immunology/immune oncology field. Extensive experience performing xenograft and syngeneic or gene-edited mouse models of cancer is required. Experience developing and executing cell-based assays. Expertise in development of in vitro/in vivo/ex vivo assays to assess immune function. Flow cytometry experience required. Molecular biology experience is strongly preferred. Excellent written and oral communication, organizational skills and time management. Ability to work independently as well as collaboratively. Adaptable to change and new challenges. Application Instructions: Applicants should send curriculum vitae, statement of research interests and experience, and contact information for three references to: Michael Lyman, PhD Email: mlyman@salk.edu

Job #: F289 Posted Date: October 1, 2018 Closes On: Open Until Filled Job Title: Research Associate - Regulatory Biology Laboratory, Dr. Katherine Jones Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Regulatory Biology Laboratory Lab research focuses on gene transcription, emphasizing the role of transcription elongation and RNAPII CTD kinases in cancer and human embryonic stem cell differentiation. Position Description: A postdoctoral position is available to study a newly-discovered pathway, which links transcription and RNAPII CTD kinases with mRNA 5-cap remodeling by mTORC1 for facilitated translation in the cytoplasm, is critical for ovarian, breast and prostate cancer metastases. The project will explore how the CDK12 kinase affects signaling under NRF2/oxidative stress conditions, as well as during human embryonic stem cell renewal and differentiation. A novel regulator of CDK12, which is essential for mitochondrial oxidative phosphorylation will also be characterized and studied for insights to inhibit this step in cancer. Prior experience with ChIP-seq,RNA-seq, imaging, and molecular and biochemical/proteomics techniques would be relevant. Education: PhD degree in Biological Sciences. Experience: Recent PhD with experience with mammalian cell culture, protein biochemistry, chromatin and/or gene expression analysis including chromatin immunoprecipitation. Application Instructions: Application Instructions: Please email Curriculum Vitae, a statement of research interests, and three letters of reference to: jones@salk.edu

  Job #: F670 Posted Date: July 18, 2017 Closes On: Open Until Filled Job Title: Research Associate - Nomis Center Immunobiology and Microbial Pathogenesis, Dr. Bjorn Lillemeier Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis The Lillemeier laboratory is part of the Nomis Center for Immunobiology and the WAITT Advance Biophotonics Center. Research in the laboratory focuses on how T cell activities and functions are initiated and controlled during adaptive immune responses. Using cutting edge imaging, structural and biological approaches the lab studies the organization of proteins in the space and time to uncover how T cell signaling pathways are assembled and dissociated. Our goal is to modulate molecular mechanisms of T cell signaling to alter immune responses and find alternatives to current immunotherapies. Position Description: A postdoctoral position is available to study the effects of mutations in signaling the molecules (specifically of Zap70 and Shp2) on T cell immune responses in vitro and in vivo. The goal of these studies is to determine if plasma membrane proximal signaling mechanisms can be targeted in the future immunotherapies. The study will utilize animals models for cancel and autoimmunity, as well as T cell lines and ex vivo primary T cells from wild type and TCR transgenic mice. The position requires a strong background in cell biology or cellular immunology. Experience with animal models and in molecular biology will be beneficial. A successful candidate will be trained in specific technologies and methods required for the project. For more information on the Lillemeier lab, please visit our webpage Lillemeier Laboratory Education: Ph.D. in required Experience: Background in cellular immunology/biology and animal models (e.g. for autoimmunity and/or cancer) is preferred. Rudimentary skills in molecular biology are beneficial to the position. Application Instructions: Email Dr. Bjorn Lillemeier a brief cover letter describing your background and research interests, your CV, and contact information for 2-3 references.   Contact Information: Bjorn Lillemeier, Ph.D. Nomis Center for Immunobiology and Microbial Pathogenesis Waitt Advanced Biophotonics Center Salk Institute for Biological Studies 10010 N Torrey Pines Rd La Jolla, CA 92037 Email: blillemeier@salk.edu Lillemeier Laboratory Website  

Job #: F708 Posted Date: February 14, 2019 Closes On: Open Until Filled Job Title: Postdoctoral Position - Molecular and Cell Biology Laboratory, Dr. Patrick Hsu Status: Regular Full Time Benefits Eligible: Yes Laboratory/Department: Molecular and Cell Biology Laboratory Are you passionate about engineering and repairing life? Inventing technologies and editing the genome? The Hsu Lab at the Salk Institute for Biological Studies in La Jolla, CA ( http://hsu.salk.edu ) works at the intersection of bioengineering and genomics to interrogate the human genome, develop precision genetic therapies, and invent new technologies for genome and transcriptional engineering. Position Description: We are seeking highly motivated postdoctoral fellows who are interested in developing and applying novel molecular technologies to systematically reverse-engineer cellular processes through rapid and precise perturbations (Hsu Cell 2014). This position is part of a National Institutes of Aging-funded team to establish and characterize stem cell-derived models of Alzheimer’s disease using high-throughput genome editing and CRISPR-based functional genomics screens. We aim to mechanistically define genetic pathways that collaborate to induce neuronal degeneration, and identify novel targets for therapeutic intervention. Education: Candidates should have a Ph.D. or M.D. degree and experience in stem cell biology and molecular/cellular biology. Experience: Significant experience with mammalian tissue culture, molecular biology and genomics techniques (cloning, RNA-seq, ChIP, etc.), and a stem cell biology or neurobiology background is preferred. Application Instructions: Please submit your CV, statement of research interests and experience, and references to Patrick Hsu ( patrick@salk.edu ) About the Salk Institute: The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probes fundamental life science questions in a unique, collaborative and creative environment. Focused both on discovery and on mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes and infectious diseases by studying neuroscience, genetics, cell and plant biology, and related disciplines. Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, MD, the Institute is an independent nonprofit organization and architectural landmark. Overlooking the Pacific Ocean in La Jolla, the Salk Institute offers a warm, collegial and collaborative work environment, where employees enjoy a generous benefits program. Social activities on campus encourage interaction as a community.