Salk Institute for Biological Studies

The Panda and Engle Labs are recruiting for a joint post-doctoral position to study connective tissue regeneration. In this fully funded collaboration, we are seeking to identify conditions, cell types, and factors that promote muscle or tendon repair and regeneration using three-dimensional organoid models. Ultimately, we will test the ability of these factors to optimize performance and accelerate repair in pre-clinical models.  Position Description A post-doctoral position is immediately available for team-oriented individuals with tissue culture experience. Ideal candidates should be intellectually curious, well-organized and well-versed in constructive problem solving. Experience with organoids, connective tissue biology and mouse modeling is preferred. Highlights Large, multidisciplinary team project with multiple opportunities for integration, collaboration, and networking State-of-the-art organoid pharmacotyping experience Potential for translation to...

We have multiple post-doctoral positions available for computational researchers in Talmo Pereira's lab. Our work leverages computer vision and deep learning to solve biological problems across diverse application areas, including neuroscience, plant biology and cell biology. We are looking for candidates with a strong background in computational work and looking to work closely with experimentalists to develop and apply machine learning models to tackle biological problems. Potential project areas and associated approaches include: Movement phenotyping: pose estimation, multi-animal tracking, behavior segmentation/action recognition âPlant phenotyping: shape estimation, image segmentation, multi-view reconstruction Artificial neural network-based modeling: agent-based models, imitation learning, interpretable AI, generative sequence models, probabilistic programming Specific projects will involve collaboration with experimental labs working on motor control, social...

Post-doctoral position available for individual interested in signal transduction, transcriptional regulation, and metabolism. Experience in RNA sequencing, chromatin immunoprecipitation, and in bioinformatics helpful. Candidate should enjoy working independently in a collaborative setting. Interest in metabolic physiology desirable; we have state of the art facilities to study the role of the CREB pathway in different metabolic states. Our lab also employs genetics to gain insight into the role of the CREB pathway in glucose and lipid metabolism as well as in the development of insulin resistance and type II diabetes. We use biochemical approaches to characterize regulatory components of the CREB pathway and to identify cellular CREB target genes that contribute to the underlying physiology. Mice with knockouts of CREB and CRTC family members in different tissues are employed to identify biological contexts in which this pathway is activated. Interested applicants with PhD or...

Nearly every facet of human experience is colored by the sense of sight. The effortlessness and immediacy with which this sense conveys physical, social, and aesthetic qualities of one's environment belie the extraordinary complexity of the brain mechanisms involved. Our acute dependence upon these mechanisms is brought to the fore, however, by a variety of developmental, traumatic, and disease-related disorders of visual perception and visually-guided behavior. While rarely life- threatening, such disorders can be profoundly debilitating, impairing activities that we have come to take for granted, such as reading, driving, or recognizing family and friends. We seek a thorough understanding of brain mechanisms of visual information processing, with the promise of effective treatment and remediation of disorders of vision, as well as insights into the nature of our conscious experience of the world. The specific aims of our research have been to identify how sensory signals in...

The goal in the lab is to understand the molecular and circuit mechanisms of reward-based action learning, focusing on the cortico-basal ganglia circuitry and dopamine function. Position Description:   We are currently seeking a highly motivated and independent postdoctoral fellow interested in studying the basal ganglia circuits and behavior. Research in the laboratory focuses on the molecular and circuit mechanisms of action learning and selection, using a combination of behavioral, optogenetics, slice/in vivo electrophysiology and imaging techniques. The successful candidate will employ electrophysiology and/or deep-brain imaging, together with viral tracing and optogenetics to dissect the function of specific cell types of basal ganglia circuitry in freely behaving mice. Education:   The candidate should hold a doctoral degree with a strong background in systems or cellular neuroscience. Experience:   Experience on slice or in vivo electrophysiological...

The McVicker laboratory studies how human genetic variation affects gene regulation by combining experimental approaches with computational analyses. We are especially interested in identifying pathogenic regulatory variants that act in immune cells and cancer cells. Currently, we are developing new tools to discover somatic regulatory mutations in cancer genomes, and manipulating cell lines with high-throughput CRISPR technologies to discover new regulatory sequences. In much of our research, we develop sophisticated computational and statistical methods so that we can extract subtle signals from noisy experimental data. Position Description:   Quantitative trait mapping of single cell gene expression and chromatin traits The McVicker Laboratory at the Salk Institute for Biological Studies is seeking a postdoctoral fellow to tackle cutting-edge research problems in genetics, gene regulation and chromatin biology. The successful candidate will develop new statistical...

The research focuses on important problems related to cancer initiation, detection, progression, metastasis and treatment. These projects are based on our recent observations concerning cell state plasticity that arises during cancer progression. Specifically, we are using a single cell RNA sequencing, epigenetic profiling, and developing novel in vivo and in vitro strategies involving mouse models and organoid cultures to determine how cancer cells undergo developmental reprogramming to generate intra-tumoral heterogeneity and metastasis. We use computational methods based on mouse cancer models and human databases. Our work has focused significantly on breast cancer, but new studies have taken us into exciting directions involving cell state reprogramming involving acinar-ductal metaplasia in the genesis of pancreas cancer. Our long-term goals are to devise novel strategies to intercept cells undergoing reprogramming to reduce the probability that drug resistant or metastatic...

The laboratory of Dr. Daniel Hollern at the Salk Institute of Biological Studies Department of Immunobiology and Microbial Pathogenesis in La Jolla, California seeks to recruit a Postdoctoral Fellow to engage in immuno-oncology research. The main focus of the lab is to understand the immunological and molecular landscape of tumors with the goal of leveraging the immune component to promote anti-tumor immunity. In more detail, the lab is particularly interested in developing these approaches through the study of tumor infiltrating B cells and T cells. These studies will be pursued in syngeneic, orthotopic and genetically engineered mouse models as well as patient specimens.  The lab utilizes a multidisciplinary approach blending biologically appropriate models, molecular biology, and genomic analytical techniques including single cell and spatial transcriptomics and proteomics to interrogate pertinent questions in a number of in vitro and in vivo translational studies of breast...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. Description:   The Kosuri Lab at the Salk Institute for Biological Studies seeks to recruit multiple Postdoctoral Fellows to engage in integrative biology research. The lab has two tracks: 1) single-molecule studies of protein-DNA interactions, using methods based on DNA origami and super resolution microscopy; and 2) Cardiac biology studies in mouse models and humans, using genetic and imaging approaches including new methods for single-cell spatial transcriptomics. The postdoctoral positions are for scientists looking to invent and deploy new technology to uncover foundational principles in biology. Ideal candidates are excited to join a...

Description The Michael Group in the Plant Molecular and Cellular Biology Laboratory at the Salk focuses on sequencing, assembling and analyzing plant genomes. A broad objective is to build genome resources for plants with unique morphological or lifestyle characteristics (carnivorous, parasitic), minimal plants (duckweed), and crop wild relatives (CWR), to better understand plant genome organization and trait architecture. Currently we are working on several different strategies to generate chromosome-level haplotype-resolved polyploid genomes. In addition, we are developing new techniques to annotate (coding and non-coding) non-model plant genomes using single-cell sequencing, direct DNA modification detection, and computational approaches. We are developing reference-free pan-genome methods for integration into genome wide selection studies (GWAS) and genomic selection paradigms to link population level phenotypes to gene networks underlying environmental response and...

Position description Our research employs cross-disciplinary approaches (genetics, transcriptomics, circuit tracing, functional imaging, quantitative behavioral analyses) to elucidate the roles played by genes and neurons in social behavior. An ideal postdoctoral fellow candidate would have a demonstrated expertise in the following fields: Biochemistry and bioinformatics. We seek a candidate who has both bench and quantitative data analysis experience in transcriptomics. Using our 10X Genomics single cell transcriptome platform, we intend to characterize genes responsible for flexible behavioral modulations during social interactions in both flies and unconventional animal models, such as honey bees and paper wasps. Neurophysiology. We seek a candidate who is familiar with techniques for monitoring activities of neurons in vivo , such as electrophysiology and functional imaging. We are in the process of expanding our functional imaging capacity to be able to monitor...

The Engle Lab focuses on understanding the etiology of pancreatitis and pancreatic cancer to develop better prevention, diagnostic, and treatment strategies. We study the impact of altered glycosylation on the cross-talk between ductal cells with their microenvironment during disease pathogenesis as well as the role of tobacco-related carcinogens in priming the pancreas for transformation. We rely heavily on three-dimensional organoid mono- and co-culture systems as well as genetically engineered mouse models.  Position Description Fully funded Post-doctoral positions are immediately available for individuals with a good understanding of cancer and disease modeling. Ideal candidates should be intellectually curious, well-organized and well-versed in constructive problem solving. Experience with cell culture and mouse modeling is preferred. Education:   Ph.D. or M.D./Ph.D. in Biological Sciences or related fields.  

We have multiple post-doctoral positions available in the Towers lab. Our work combines basic cell biology techniques and physiologically relevant cancer models to ask how cancer cells adapt when essential cellular recycling processes are blocked. We are looking for self-motivated and inquisitive scientist to join the team. Applicants should have a solid background in cancer biology and/or cell biology techniques with an eagerness to learn more. Additional skills in mouse models of cancer, optogenetics, cell metabolism, autophagy, and/or mitochondrial biology would be preferred.  To learn more about the lab here: https://towers.salk.edu/ Responsibilities: Perform investigational studies to understand how cancer models to ask how cancer cells adapt when essential cellular recycling processes are blocked. Perform cell biology experiments and/or perform in-vivo experiments in animal models such as mice or zebra fish. Execute experiments independently and contribute to...

The Busch Group aims to understand which genes, genetic networks, and molecular processes determine root growth and its responses to the environment. This research is directly leveraged in the pioneering CRoPS project that aims to develop crop plants that sequester more carbon via extensive root systems containing recalcitrant carbon polymers to fight climate change. For this we are working to enhance the carbon sequestration capacity in several important crop species. We are currently seeking a highly motivated and independent postdoctoral fellow interested in studying the mechanisms controlling root traits in Canola. The ideal candidate will be a plant biologist who has experience working with Canola and has expertise in root phenotyping, quantitative genetics and plant molecular biology. Ideal candidates should be intellectually curious, highly productive, driven to uncover new and impactful biology and to apply this knowledge to the larger problem of climate change, and...

Laboratory research focuses on how genes and molecules orchestrate the development of an embryo. The knowledge obtained may help to discover new molecules and specific gene/cell treatments to prevent and cure diseases affecting mankind both in the adult and embryonic stages, as well as inducing endogenous in vivo regenerative responses that may allow for tissue and organ regeneration and slowing down the aging process. Position Description:   Funded post-doctoral positions are immediately available for individuals with a good grounding in molecular and/or developmental biology, methods such as CRISPR mediated genome editing, RNA sequencing and epigenetics. Knowledge of bioinformatics is also very desirable. Ideal candidates should be intellectually curious, productive, and enjoy working in a committed team effort to make these important projects succeed. The projects are well under way due to the efforts of a dedicated group of post-docs, technicians and undergrads....

The Chalasani lab at Salk is seeking ambitious and motivated post-doctoral fellows to join their Sonogenetics team. The goal of this project is to develop a new non-invasive method to manipulate neurons and non-neuronal cells ( www.sonogenetics.salk.edu ). Our manuscript demonstrating the efficacy of this method in mice was recently posted on bioarxiv ( https://www.biorxiv.org/content/10.1101/2020.10.14.338699v1 ).  We are planning to identify and validate new channel candidates and variants for use across model systems to achieve both excitation and inhibition non invasively.  Additionally, this project involves collaborating with engineers, bioinformaticians, protein biochemists and theoretical modelers.  We are particularly interested in individuals with expertise in electrophysiology (in vitro and in vivo) and/or mouse behavior and neural circuit analysis. Please contact the PI ( schalasani@salk.edu ) with your resume and names of referees who can speak to your skills.

Application Instructions: Employment History   Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. Job location is in Salk North (Torrey Pines) In partnership with the Sr. Director, Human Resources and HR Managers, ensures compliance in HR-related functions and makes recommendations for change as needed. Determines and recommends employment practices necessary to establish a positive employer-employee relationship and promote a high level of employee morale. Position provides objective advice to personnel and supervisors regarding conflict, disputes, employment regulations, job performance, conduct and disciplinary process.  Negotiates, mediates, and investigates employment issues. Interprets and advises on application of Institute and...

We are currently seeking a highly motivated and independent postdoctoral fellow interested in studying the spatial and temporal regulation of root genes using single-cell genomics and other high throughput phenotyping techniques.  The ideal candidate will be a plant biologist who has experience in next generation sequencing techniques, root phenotyping, and molecular biology. The candidate should be independently motivated, scientifically inquisitive, and eager to discover new gene regulatory mechanisms that can be leveraged to tackle the larger issue of climate change. The postdoc will join a diverse team of plant biologists with expertise in bioinformatics, molecular biology, epigenetics and chromatin. Education : Ph.D. in Biological Sciences, Agricultural or Plant Biology or related fields Application Instructions : Applicants should submit a current resume, names of three references, and an indication of how their expertise and academic accomplishments make them a...

We are currently seeking a highly motivated and independent postdoctoral fellow interested in using microscopy to assess the levels carbon-rich plant biopolymers, like suberin, in the roots of model plants as well as select row and cover crops and to uncover the in planta gene expression patterns underlying these traits.   The ideal candidate will be a plant biologist who has experience in root phenotyping, including confocal microscopy and in situ hybridization techniques. The candidate should be independently motivated, scientifically inquisitive, and eager to discover new gene regulatory mechanisms that can be leveraged to tackle the larger issue of climate change. The postdoc will join a diverse team of plant biologists with expertise in bioinformatics, molecular biology, epigenetics and chromatin. Education : Ph.D. in Biological Sciences, Agricultural or Plant Biology or related fields Application Instructions : Applicants should submit a current resume, names...

We are currently seeking a highly motivated and independent postdoctoral fellow interested in using genetic engineering to enhance the levels of carbon-rich plant biopolymers, like suberin, in the roots of model plants as well as select row and cover crops. The ideal candidate will be a plant biologist who has experience in genetic engineering techniques, root phenotyping, and gene expression assays. The candidate should be independently motivated, scientifically inquisitive, and eager to discover new gene regulatory mechanisms that can be leveraged to tackle the larger issue of climate change. The postdoc will join a diverse team of plant biologists with expertise in bioinformatics, molecular biology, epigenetics and chromatin. Education : Ph.D. in Biological Sciences, Agricultural or Plant Biology or related fields Application Instructions : Applicants should submit a current resume, names of three references, and an indication of how their expertise and academic...