288 jobs found in california

The research focuses on important problems related to cancer initiation, detection, progression, metastasis and treatment. These projects are based on our recent observations concerning cell state plasticity that arises during cancer progression. Specifically, we are using a single cell RNA sequencing, epigenetic profiling, and developing novel in vivo and in vitro strategies involving mouse models and organoid cultures to determine how cancer cells undergo developmental reprogramming to generate intra-tumoral heterogeneity and metastasis. We use computational methods based on mouse cancer models and human databases. Our work has focused significantly on breast cancer, but new studies have taken us into exciting directions involving cell state reprogramming involving acinar-ductal metaplasia in the genesis of pancreas cancer. Our long-term goals are to devise novel strategies to intercept cells undergoing reprogramming to reduce the probability that drug...

The laboratory of Dr. Daniel Hollern at the Salk Institute of Biological Studies Department of Immunobiology and Microbial Pathogenesis in La Jolla, California seeks to recruit a Postdoctoral Fellow to engage in immuno-oncology research. The main focus of the lab is to understand the immunological and molecular landscape of tumors with the goal of leveraging the immune component to promote anti-tumor immunity. In more detail, the lab is particularly interested in developing these approaches through the study of tumor infiltrating B cells and T cells. These studies will be pursued in syngeneic, orthotopic and genetically engineered mouse models as well as patient specimens.  The lab utilizes a multidisciplinary approach blending biologically appropriate models, molecular biology, and genomic analytical techniques including single cell and spatial transcriptomics and proteomics to interrogate pertinent questions in a number of in vitro and in vivo translational...

Position description Our research employs cross-disciplinary approaches (genetics, transcriptomics, circuit tracing, functional imaging, quantitative behavioral analyses) to elucidate the roles played by genes and neurons in social behavior. An ideal postdoctoral fellow candidate would have a demonstrated expertise in the following fields: Biochemistry and bioinformatics. We seek a candidate who has both bench and quantitative data analysis experience in transcriptomics. Using our 10X Genomics single cell transcriptome platform, we intend to characterize genes responsible for flexible behavioral modulations during social interactions in both flies and unconventional animal models, such as honey bees and paper wasps. Neurophysiology. We seek a candidate who is familiar with techniques for monitoring activities of neurons in vivo , such as electrophysiology and functional imaging. We are in the process of expanding our functional imaging capacity to be...

We have multiple post-doctoral positions available in the Towers lab. Our work combines basic cell biology techniques and physiologically relevant cancer models to ask how cancer cells adapt when essential cellular recycling processes are blocked. We are looking for self-motivated and inquisitive scientist to join the team. Applicants should have a solid background in cancer biology and/or cell biology techniques with an eagerness to learn more. Additional skills in mouse models of cancer, optogenetics, cell metabolism, autophagy, and/or mitochondrial biology would be preferred.  To learn more about the lab here: https://towers.salk.edu/ Responsibilities: Perform investigational studies to understand how cancer models to ask how cancer cells adapt when essential cellular recycling processes are blocked. Perform cell biology experiments and/or perform in-vivo experiments in animal models such as mice or zebra fish. Execute experiments independently...

The Panda and Engle Labs are recruiting for a joint post-doctoral position to study connective tissue regeneration. In this fully funded collaboration, we are seeking to identify conditions, cell types, and factors that promote muscle or tendon repair and regeneration using three-dimensional organoid models. Ultimately, we will test the ability of these factors to optimize performance and accelerate repair in pre-clinical models.  Position Description A post-doctoral position is immediately available for team-oriented individuals with tissue culture experience. Ideal candidates should be intellectually curious, well-organized and well-versed in constructive problem solving. Experience with organoids, connective tissue biology and mouse modeling is preferred. Highlights Large, multidisciplinary team project with multiple opportunities for integration, collaboration, and networking State-of-the-art organoid pharmacotyping experience Potential for...

The Stites Laboratory combines experimental, computational, and systems approaches to study cancer and disease. We have a historic emphasis on the RAS pathway.  Currently available projects include  (i) studies of cancers driven by non-canonical RAS pathway mutations; (ii) functional genomic and systems biology studies to identify new approaches for targeting cancer.  Additional projects that apply the systems biology perspective to the study of the RAS pathway are also available. The laboratory is comprised of both experimental and computational scientists, although individual scientists tend to be either experimental or computational.  Collaborations between experimental and computational scientists are common, and provide an opportunity to enrich one's science and to expedite progress on one's main project(s).     Experience with experimental cellular and molecular biology is required for experimental postdocs.  Ideal candidates for the specific...

We are currently seeking a highly motivated and independent postdoctoral fellow interested in using genetic engineering to enhance the levels of carbon-rich plant biopolymers, like suberin, in the roots of model plants as well as select row and cover crops. The ideal candidate will be a plant biologist who has experience in genetic engineering techniques, root phenotyping, and gene expression assays. The candidate should be independently motivated, scientifically inquisitive, and eager to discover new gene regulatory mechanisms that can be leveraged to tackle the larger issue of climate change. The postdoc will join a diverse team of plant biologists with expertise in bioinformatics, molecular biology, epigenetics and chromatin. Education : Ph.D. in Biological Sciences, Agricultural or Plant Biology or related fields Application Instructions : Applicants should submit a current resume, names of three references, and an indication of how their...

We are currently seeking a highly motivated and independent postdoctoral fellow interested in using microscopy to assess the levels carbon-rich plant biopolymers, like suberin, in the roots of model plants as well as select row and cover crops and to uncover the in planta gene expression patterns underlying these traits.   The ideal candidate will be a plant biologist who has experience in root phenotyping, including confocal microscopy and in situ hybridization techniques. The candidate should be independently motivated, scientifically inquisitive, and eager to discover new gene regulatory mechanisms that can be leveraged to tackle the larger issue of climate change. The postdoc will join a diverse team of plant biologists with expertise in bioinformatics, molecular biology, epigenetics and chromatin. Education : Ph.D. in Biological Sciences, Agricultural or Plant Biology or related fields Application Instructions : Applicants should submit a...

We are currently seeking a highly motivated and independent postdoctoral fellow interested in studying the spatial and temporal regulation of root genes using single-cell genomics and other high throughput phenotyping techniques.  The ideal candidate will be a plant biologist who has experience in next generation sequencing techniques, root phenotyping, and molecular biology. The candidate should be independently motivated, scientifically inquisitive, and eager to discover new gene regulatory mechanisms that can be leveraged to tackle the larger issue of climate change. The postdoc will join a diverse team of plant biologists with expertise in bioinformatics, molecular biology, epigenetics and chromatin. Education : Ph.D. in Biological Sciences, Agricultural or Plant Biology or related fields Application Instructions : Applicants should submit a current resume, names of three references, and an indication of how their expertise and academic...

The Manor Laboratory at the Waitt Advanced Biophotonics Center has been established at the Salk Institute for Biological Studies as a state-of-the-art research hub to provide advanced and emerging imaging modalities to enable unprecedented insights into the inner workings of cells, tissues and organisms. We are seeking a candidate with experience in hearing research and will be establishing and performing independent research and analysis on projects that involve the study of hearing loss, inner ear sensory hair cells, neurons, and cell cultures.  Cell and tissue culture, microscopy (training will be available), and various cellular and molecular biology techniques will be an essential part of this research. Murine models of hearing loss and neurodegenerative disorders are heavily employed in the lab. May provide task instruction, training, and guidance to lower-level personnel. To learn more about the lab here:  https://www.salk.edu/scientist/uri-manor/...

The Engle Lab focuses on understanding the etiology of pancreatitis and pancreatic cancer to develop better prevention, diagnostic, and treatment strategies. We study the impact of altered glycosylation on the cross-talk between ductal cells with their microenvironment during disease pathogenesis as well as the role of tobacco-related carcinogens in priming the pancreas for transformation. We rely heavily on three-dimensional organoid mono- and co-culture systems as well as genetically engineered mouse models.  Position Description Fully funded Post-doctoral positions are immediately available for individuals with a good understanding of cancer and disease modeling. Ideal candidates should be intellectually curious, well-organized and well-versed in constructive problem solving. Experience with cell culture and mouse modeling is preferred. Education:   Ph.D. or M.D./Ph.D. in Biological Sciences or related fields.

Post-doctoral position available for individual interested in signal transduction, transcriptional regulation, and metabolism. Experience in RNA sequencing, chromatin immunoprecipitation, and in bioinformatics helpful. Candidate should enjoy working independently in a collaborative setting. Interest in metabolic physiology desirable; we have state of the art facilities to study the role of the CREB pathway in different metabolic states. Our lab also employs genetics to gain insight into the role of the CREB pathway in glucose and lipid metabolism as well as in the development of insulin resistance and type II diabetes. We use biochemical approaches to characterize regulatory components of the CREB pathway and to identify cellular CREB target genes that contribute to the underlying physiology. Mice with knockouts of CREB and CRTC family members in different tissues are employed to identify biological contexts in which this pathway is activated. Interested...

Nearly every facet of human experience is colored by the sense of sight. The effortlessness and immediacy with which this sense conveys physical, social, and aesthetic qualities of one's environment belie the extraordinary complexity of the brain mechanisms involved. Our acute dependence upon these mechanisms is brought to the fore, however, by a variety of developmental, traumatic, and disease-related disorders of visual perception and visually-guided behavior. While rarely life- threatening, such disorders can be profoundly debilitating, impairing activities that we have come to take for granted, such as reading, driving, or recognizing family and friends. We seek a thorough understanding of brain mechanisms of visual information processing, with the promise of effective treatment and remediation of disorders of vision, as well as insights into the nature of our conscious experience of the world. The specific aims of our research have been to identify how...

The McVicker laboratory studies how human genetic variation affects gene regulation by combining experimental approaches with computational analyses. We are especially interested in identifying pathogenic regulatory variants that act in immune cells and cancer cells. Currently, we are developing new tools to discover somatic regulatory mutations in cancer genomes, and manipulating cell lines with high-throughput CRISPR technologies to discover new regulatory sequences. In much of our research, we develop sophisticated computational and statistical methods so that we can extract subtle signals from noisy experimental data. Position Description:   Quantitative trait mapping of single cell gene expression and chromatin traits The McVicker Laboratory at the Salk Institute for Biological Studies is seeking a postdoctoral fellow to tackle cutting-edge research problems in genetics, gene regulation and chromatin biology. The successful candidate will develop...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY Provides support to end users on a variety of issues in a unique BYOD (bring-your-own-device) environment. Identifies, researches, and resolves technical problems. Responds to telephone calls, email and personnel requests for technical support. Resolves issues using language that conveys technical information to non-technical end-users. Documents, tracks and monitors the problem to ensure a timely resolution. Collaborates/escalates with IT colleagues when necessary to resolve issues. ESSENTIAL FUNCTIONS Help Desk Support (70%) Performs front line user support activities and functions including...

The South Orange County Community College District is committed to creating an academic and work environment that fosters diversity, equity and inclusion and equal opportunity for all, and ensures that students, faculty, management and staff of all backgrounds feel welcome, included, supported, and safe. Our culture of belonging, openness, and inclusion, makes our district a unique and special place for individuals of all backgrounds.  Our District and our colleges are looking for equity and inclusion-minded applicants who represent the full diversity of California and who demonstrate a sensitivity to the understanding of diverse academic, socioeconomic, cultural, disability, gender identity, sexual orientation, and ethnic backgrounds present within our community. When you join our District, you can expect to be part of an exciting, thriving, equity-focused, and inclusive community that approaches higher education with the lens of social justice and collaboration among students,...

  Antelope Valley College   Superintendent / President Salary: $237,382.70 Annually Deadline: The position is open until filled. The deadline for application materials to be included in the first review by the Search Committee is at Noon on Friday, February 25, 2022.  All inquiries, nominations, and applications will be held in the strictest confidence.   Complete job description and application available online at: http://50.73.55.13/counter.php?id=219322   DESCRIPTION The Antelope Valley Community College District (AVCCD) Board of Trustees invites applications for the position of Superintendent/President. Prospective applicants are encouraged to both review this announcement and, for a more thorough profile of the College, its students and community, the executive search website.   Position Description:  The Superintendent/President is the Chief Executive Officer of the AVCCD and...

Application Instructions: Employment History   Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment.  Position is responsible for provision of quality clinical veterinary care for all animals maintained at The Salk Institute. This includes preventative medicine, quarantine, surveillance, diagnosis, treatment and control of disease, anesthesia and analgesia, surgery and post-surgical care, euthanasia and clinical services directly related to research protocols. Position serves as a critical liaison between research investigators and the Animal Resources Department (ARD). Oversees Veterinary Services and Colony Management teams and may provide leadership across ARD as needed in support or behalf of Sr. Director. ESSENTIAL FUNCTIONS AND RESPONSIBILITIES: Veterinary Care 40% Provides clinical...

The South Orange County Community College District is committed to creating an academic and work environment that fosters diversity, equity and inclusion and equal opportunity for all, and ensures that students, faculty, management and staff of all backgrounds feel welcome, included, supported, and safe. Our culture of belonging, openness, and inclusion, makes our district a unique and special place for individuals of all backgrounds.  Our District and our colleges are looking for equity and inclusion-minded applicants who represent the full diversity of California and who demonstrate a sensitivity to the understanding of diverse academic, socioeconomic, cultural, disability, gender identity, sexual orientation, and ethnic backgrounds present within our community. When you join our District, you can expect to be part of an exciting, thriving, equity-focused, and inclusive community that approaches higher education with the lens of social justice and collaboration among students,...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY This position is responsible for routine processing of clean and soiled cages and accessories, maintenance and general janitorial duties in animal facilities, equipment maintenance, basic QA testing, processing deliveries from vendors and performing basic rodent husbandry tasks based on standard operating procedures and training to ensure compliance with the Guide for the Care and Use of Laboratory Animals, the Animal Welfare Act and Regulations as well as all applicable federal, state, local and institutional laws, regulations, policies and guidelines. Candidates with backgrounds in custodial work or experience in restaurant...