University of Pennsylvania
Philadelphia, PA
Postdoctoral Position in Diabetic Fracture Healing, FOXO1, Primary Cilia, and Regenerative Biomaterialsled Position Location: Penn Dental Medicine Open Date: Jun 02, 2026 Deadline: Open to applications from U.S. Citizens and foreign nationals A postdoctoral position is available in the laboratory of Dr. Dana Graves, University of Pennsylvania, to study why diabetes disrupts fracture healing and to develop a new local therapeutic strategy to restore bone repair. This project builds on compelling data showing that lineage-specific deletion of FOXO1 in chondrocytes or osteoblasts fully rescues diabetes-impaired fracture healing, as measured by histology, microCT, and mechanical testing. We have also found that loss of primary cilia in these same skeletal lineages reproduces key features of diabetic fracture healing. Together, these findings point to a novel FOXO1-primary cilia axis as a central regulator of skeletal repair in diabetes. The successful candidate will...