University of Pennsylvania
Philadelphia, PA
Postdoctoral Position in Skeletal Regeneration, Diabetes, and Spatial Biology Location: University of Pennsylvania - Penn Dental Open Date: Jul 21, 2026 Deadline: A postdoctoral position is available in the laboratory of Dr. Dana Graves at the University of Pennsylvania's School of Dental Medicine, Department of Periodontics, to investigate a newly identified mechanism through which diabetes impairs fracture healing and to develop a locally delivered therapeutic strategy to restore skeletal repair. The project is supported by strong preliminary evidence demonstrating that lineage-specific deletion of FOXO1 in chondrocytes or osteoblasts reverses diabetes-impaired fracture healing. We have also found that disruption of primary cilia in these skeletal lineages reproduces defining features of defective repair in diabetes. Together, these findings identify and strongly support a previously unrecognized FOXO1-primary cilia signaling axis as an important regulator of...