5 senior research investigator jobs found in Philadelphia, PA

Postdoctoral Fellow in Cancer Biology Location: University of Pennsylvania - Perelman School of Medicine Open Date: Oct 03, 2025 Deadline: Faculty Mentor: Carman Li, Ph.D. Department: Cancer Biology Funding Source: PI Grants Number of Positions: 2 Lab Website: www.CarmanLiLab.org Open to U.S. citizens and foreign nationals. The Carman Li Lab studies hereditary cancer development and their implications for sporadic cancer interception. A special focus is on breast cancer driven by germline mutations in the tumor suppressor gene BRCA1. The lab is recruiting postdoctoral fellows to investigate the molecular mechanisms and intervention strategies for BRCA1-related breast cancer. The fellows will lead their independent research projects using advanced genetically engineered mouse models, 3D organoid cultures, single-cell omics, patient sample analyses, and other approaches. This is an excellent opportunity to contribute to cutting-edge research and...

Postdoctoral Researchers - bench and dry lab scientists in the field of lipoprotein metabolism and the role of lipids in cardiometabolic traits and diseases (including atherosclerosis and metabolic dysfunction-associated steatotic liver disease or MASLD) Location: University of Pennsylvania - Perelman School of Medicine Open Date: Apr 17, 2026 Deadline: Faculty Mentor: Daniel J. Rader MD Hiring Department: Medicine - Division of Translational Medicine and Human Genetics Funding Sources: NIH and AHA grants Number of Positions: 2 U.S. citizens and foreign nationals may apply. Applications are invited for postdoctoral positions in the laboratory of Dr. Daniel J. Rader , Departments of Medicine and Genetics at the Perelman School of Medicine (PSOM) of the University of Pennsylvania. The Rader lab is a multidisciplinary research environment focused on leveraging human gene discovery to elucidate the biology and molecular physiology of genes and pathways that...

Postdoctoral Scholar in Viral Immunology Location: University of Pennsylvania - School of Veterinary Medicine Open Date: Apr 10, 2026 Deadline: Faculty Mentor: Oyebola Oyesola, DVM, PhD Department: Pathobiology Funding Source: Institutional funds. Shortlisted scholars will be encouraged to apply for external fellowship and funds. Number of Positions: 1 Open to applications from U.S. citizens and foreign nationals. We are seeking a highly motivated Postdoctoral Scholar to join an interdisciplinary research program focused on viral and parasite immunology. The successful candidate will investigate immune responses to viral and parasitic infection (with an opportunity to learn this on the job), with an emphasis on mechanisms of host defense and the effect of an individual's infection history on subsequent exposure. The position offers a positive research environment with access to state-of-the-art facilities and opportunities for collaborations but within and outside...

Postdoctoral Position: HostPathogenMicrobiome Interactions Location: University of Pennsylvania - Perelman School of Medicine Open Date: Oct 06, 2025 Deadline: Faculty mentor: Jay Zhu, PhD Department: Microbiology Funding source: NIH Number of position: 1 Open to applications from U.S. citizens and foreign nationals The lab seeks a highly motivated postdoctoral researcher to investigate molecular and cellular mechanisms at the interface of host, bacterial pathogen, and commensal microbiota, with emphasis on how microbial communities modulate immunity and infection outcomes. The successful candidate will investigate microbial virulence strategies, host immune responses, and the dynamic interplay between infectious agents, microbiome, and host physiology using state-of-the-art genetics, imaging, and biochemical approaches. Qualifications Ph.D. in microbiology, immunology, molecular/cell biology, bioengineering, or related fields; strong record...

Postdoctoral researcher in neurodegenerative disease and cancer Location: University of Pennsylvania - Perelman School of Medicine Open Date: Mar 14, 2026 Deadline: The laboratory of Professor Xiaolu Yang at the Perelman School of Medicine, University of Pennsylvania, is seeking a highly motivated postdoctoral researcher to join our dynamic and interdisciplinary team. Our work investigates the fundamental mechanisms that drive neurodegenerative disease and cancer, with current projects centered around two major research areas: 1. Protein quality control, aging, and neurodegenerative diseases Our laboratory has discovered two previously unrecognized protein quality control (PQC) systems involving tripartite motif (TRIM) proteins and poly-Asp/Glu (polyD/E) proteins. These pathways function independently of ATP and exhibit distinct evolutionary conservation-TRIM in animals and polyD/E across eukaryotes-setting them apart from established PQC mechanisms....