University of Pennsylvania
Philadelphia, PA
Postdoc fellow – CRISPR screens in hematopoietic stem cells to study replication fitness Location: University of Pennsylvania, Perelman School of Medicine Open Date: Jul 31, 2026 Deadline: A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Dr. Tong's laboratory studies cytokine receptor signaling in replication stress , DNA repair , and ubiquitin signaling in hematopoietic stem cells , bone marrow failure , and leukemia . Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation, and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Genome integrity plays a critical role in blood...