19 jobs found in san diego

  The Engle Lab focuses on understanding the etiology of pancreatitis and pancreatic cancer to develop better prevention, diagnostic, and treatment strategies. We study the impact of altered glycosylation on the cross-talk between ductal cells with their microenvironment during disease pathogenesis as well as the role of tobacco-related carcinogens in priming the pancreas for transformation. We rely heavily on three-dimensional organoid mono- and co-culture systems as well as genetically engineered mouse models.  Position Description Post-doctoral positions are immediately available for individuals with a good understanding of cancer and disease modeling. Ideal candidates should be intellectually curious, well-organized and well-versed in constructive problem solving. Experience with cell culture and mouse modeling is preferred. Education:   Ph.D. or M.D./Ph.D. in Biological Sciences or related fields.    

  Laboratory research focuses on how genes and molecules orchestrate the development of an embryo. The knowledge obtained may help to discover new molecules and specific gene/cell treatments to prevent and cure diseases affecting mankind both in the adult and embryonic stages, as well as inducing endogenous in vivo regenerative responses that may allow for tissue and organ regeneration and slowing down the aging process. Position Description:   Funded post-doctoral positions are immediately available for individuals with a good grounding in molecular and/or developmental biology, methods such as CRISPR mediated genome editing, RNA sequencing and epigenetics. Knowledge of bioinformatics is also very desirable. Ideal candidates should be intellectually curious, productive, and enjoy working in a committed team effort to make these important projects succeed. The projects are well under way due to the efforts of a dedicated group of post-docs, technicians and...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. The Salk Institute Animal Resources Department (ARD) has one (1) position open for a Residency in Laboratory Animal Medicine (LAM) starting September 6th, 2021. The program is designed to prepare veterinarians for a career in LAM. The residency is approved by the American College of Laboratory Animal Medicine (ACLAM) and fulfills eligibility requirements for the ACLAM certifying examination. The resident will rotate within the ARD services and gain experience in the medical, surgical, anesthetic and behavioral management of a variety of laboratory animal models used at the Institute, including, but not limited to, mice, rats, rabbits, guinea pigs,...

Post-doctoral position available for individual interested in signal transduction, transcriptional regulation, and metabolism. Experience in RNA sequencing, chromatin immunoprecipitation, and in bioinformatics helpful. Candidate should enjoy working independently in a collaborative setting. Interest in metabolic physiology desirable; we have state of the art facilities to study the role of the CREB pathway in different metabolic states. Our lab also employs genetics to gain insight into the role of the CREB pathway in glucose and lipid metabolism as well as in the development of insulin resistance and type II diabetes. We use biochemical approaches to characterize regulatory components of the CREB pathway and to identify cellular CREB target genes that contribute to the underlying physiology. Mice with knockouts of CREB and CRTC family members in different tissues are employed to identify biological contexts in which this pathway is activated. Interested applicants with PhD or...

Nearly every facet of human experience is colored by the sense of sight. The effortlessness and immediacy with which this sense conveys physical, social, and aesthetic qualities of one's environment belie the extraordinary complexity of the brain mechanisms involved. Our acute dependence upon these mechanisms is brought to the fore, however, by a variety of developmental, traumatic, and disease-related disorders of visual perception and visually-guided behavior. While rarely life- threatening, such disorders can be profoundly debilitating, impairing activities that we have come to take for granted, such as reading, driving, or recognizing family and friends. We seek a thorough understanding of brain mechanisms of visual information processing, with the promise of effective treatment and remediation of disorders of vision, as well as insights into the nature of our conscious experience of the world. The specific aims of our research have been to identify how sensory signals in...

The goal in the lab is to understand the molecular and circuit mechanisms of reward-based action learning, focusing on the cortico-basal ganglia circuitry and dopamine function. Position Description:   We are currently seeking a highly motivated and independent postdoctoral fellow interested in studying the basal ganglia circuits and behavior. Research in the laboratory focuses on the molecular and circuit mechanisms of action learning and selection, using a combination of behavioral, optogenetics, slice/in vivo electrophysiology and imaging techniques. The successful candidate will employ electrophysiology and/or deep-brain imaging, together with viral tracing and optogenetics to dissect the function of specific cell types of basal ganglia circuitry in freely behaving mice. Education:   The candidate should hold a doctoral degree with a strong background in systems or cellular neuroscience. Experience:   Experience on slice or in vivo electrophysiological...

Laboratory research focuses on how genes and molecules orchestrate the development of an embryo. The knowledge obtained may help to discover new molecules and specific gene/cell treatments to prevent and cure diseases affecting mankind both in the adult and embryonic stages, as well as inducing endogenous in vivo regenerative responses that may allow for tissue and organ regeneration. Position Description:   Funded post-doctoral positions are immediately available for individuals with a good grounding in molecular and/or developmental biology, methods such as CRISPR mediated genome editing, RNA sequencing and epigenetics. Knowledge of bioinformatics is also very desirable. Ideal candidates should be intellectually curious, productive, and enjoy working in a committed team effort to make these important projects succeed. The projects are well under way due to the efforts of a dedicated group of post-docs, technicians and undergrads. Education:   Ph.D. in Biological...

The McVicker laboratory studies how human genetic variation affects gene regulation by combining experimental approaches with computational analyses. We are especially interested in identifying pathogenic regulatory variants that act in immune cells and cancer cells. Currently, we are developing new tools to discover somatic regulatory mutations in cancer genomes, and manipulating cell lines with high-throughput CRISPR technologies to discover new regulatory sequences. In much of our research, we develop sophisticated computational and statistical methods so that we can extract subtle signals from noisy experimental data. Position Description:   Quantitative trait mapping of single cell gene expression and chromatin traits The McVicker Laboratory at the Salk Institute for Biological Studies is seeking a postdoctoral fellow to tackle cutting-edge research problems in genetics, gene regulation and chromatin biology. The successful candidate will develop new statistical...

Position Description:   A postdoctoral researcher/bioinformatics specialist position is immediately available for three years to lead a project focused on tissue-specific and temporal variation in gene expression. The candidate will work in a highly collaborative team of researchers at Salk and at collaborating institutes in the U.S. Position Tasks: Compile large scale multi-tissue time-series gene expression data from rodents and non-human primates. Analyze full-length transcripts to find splice variants. Integrate gene expression and genome sequence data to find cis-acting elements. Integrate gene expression and genome sequence information to find allele specific gene expression. Comparative genomics between non-human primate, human, and rodent models. Integrate and analyze time-series gene expression and metabolomics datasets. Manage project to meet defined milestones and timeline. Coordinate efforts among the wet-lab and sequencing cores to ensure...

The Stites Laboratory studies the relationships between mutations, cancer (and other diseases), and the response to treatment. Projects typically involve a combination of experimental and computational biology, and most members of the lab are either traditional experimental biologists or purely computational scientists. Position Description:   The Stites lab is looking for experimental postdoctoral researchers who work in cancer biology, cell biology, and or biochemistry. Multiple hypothesis-driven experimental projects for which a computational biology foundation is already present are available for motivated experimental postdocs to take over as their own project. This is an excellent opportunity for high-productivity on cancer biology projects that would make one very competitive for both academic and industry positions. Education:   Ph.D. in Biological Sciences or equivalent. Experience:   Experience with cancer cell signaling, cancer biology, and/or...

The laboratory of Dr. Daniel Hollern at the Salk Institute of Biological Studies Department of Immunobiology and Microbial Pathogenesis in La Jolla, California seeks to recruit a Postdoctoral Fellow to engage in immuno-oncology research. The main focus of the lab is to understand the immunological and molecular landscape of tumors with the goal of leveraging the immune component to promote anti-tumor immunity. In more detail, the lab is particularly interested in developing these approaches through the study of tumor infiltrating B cells and T cells. These studies will be pursued in syngeneic, orthotopic and genetically engineered mouse models as well as patient specimens.  The lab utilizes a multidisciplinary approach blending biologically appropriate models, molecular biology, and genomic analytical techniques including single cell and spatial transcriptomics and proteomics to interrogate pertinent questions in a number of in vitro and in vivo translational studies of breast...

The research focuses on important problems related to cancer initiation, detection, progression, metastasis and treatment. These projects are based on our recent observations concerning cell state plasticity that arises during cancer progression. Specifically, we are using a single cell RNA sequencing, epigenetic profiling, and developing novel in vivo and in vitro strategies involving mouse models and organoid cultures to determine how cancer cells undergo developmental reprogramming to generate intra-tumoral heterogeneity and metastasis. We use computational methods based on mouse cancer models and human databases. Our work has focused significantly on breast cancer, but new studies have taken us into exciting directions involving cell state reprogramming involving acinar-ductal metaplasia in the genesis of pancreas cancer. Our long-term goals are to devise novel strategies to intercept cells undergoing reprogramming to reduce the probability that drug resistant or metastatic...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. Description:   The Kosuri Lab at the Salk Institute for Biological Studies seeks to recruit multiple Postdoctoral Fellows to engage in integrative biology research. The lab has two tracks: 1) single-molecule studies of protein-DNA interactions, using methods based on DNA origami and super resolution microscopy; and 2) Cardiac biology studies in mouse models and humans, using genetic and imaging approaches including new methods for single-cell spatial transcriptomics. The postdoctoral positions are for scientists looking to invent and deploy new technology to uncover foundational principles in biology. Ideal candidates are excited to join a...

The Chalasani lab at Salk is seeking ambitious and motivated post-doctoral fellows to join their Sonogenetics team. The goal of this project is to develop a new non-invasive method to manipulate neurons and non-neuronal cells ( www.sonogenetics.salk.edu ). Our manuscript demonstrating the efficacy of this method in mice was recently posted on bioarxiv ( https://www.biorxiv.org/content/10.1101/2020.10.14.338699v1 ).  We are planning to identify and validate new channel candidates and variants for use across model systems to achieve both excitation and inhibition non invasively.  Additionally, this project involves collaborating with engineers, bioinformaticians, protein biochemists and theoretical modelers.  We are particularly interested in individuals with expertise in electrophysiology (in vitro and in vivo) and/or mouse behavior and neural circuit analysis. Please contact the PI ( schalasani@salk.edu ) with your resume and names of referees who can speak to your skills.

Position description Our research employs cross-disciplinary approaches (genetics, transcriptomics, circuit tracing, functional imaging, quantitative behavioral analyses) to elucidate the roles played by genes and neurons in social behavior. An ideal postdoctoral fellow candidate would have a demonstrated expertise in the following fields: Biochemistry and bioinformatics. We seek a candidate who has both bench and quantitative data analysis experience in transcriptomics. Using our 10X Genomics single cell transcriptome platform, we intend to characterize genes responsible for flexible behavioral modulations during social interactions in both flies and unconventional animal models, such as honey bees and paper wasps. Neurophysiology. We seek a candidate who is familiar with techniques for monitoring activities of neurons in vivo , such as electrophysiology and functional imaging. We are in the process of expanding our functional imaging capacity to be able to monitor...

The Lyumkis Laboratory applies cryo-EM methods for structure determination of macromolecular assemblies involved in viral infection and chromatin regulation. The Manor Laboratory at the Waitt Advanced Biophotonics Center applies advanced imaging probes and microscopy techniques to visualize the inner workings of cells. We are seeking two postdoctoral candidates to work jointly with us, in conjunction with the cryo-EM facility at The Scripps Research Institute, to develop and apply novel imaging and analysis pipelines for coupling live cell dynamics with focused ion beam milling, cryo-ET, and image analysis of macromolecular assemblies in situ. Position Highlights:  Broadly involved in exciting projects to visualize macromolecular assemblies in cells using integrated structural and cellular biology approaches Utilize an array of advanced tools in live-cell and cryo-fluorescence microscopy, focused ion beam milling, cryo-electron tomography, machine learning and object...

  Job #: H036 Posted Date: March 13, 2020 Closes On: Open Until Filled Job Title: Salk Fellows Status: Regular Full Time Benefits Eligible: Yes Position Description: The Salk Fellows Program is a path for exceptionally talented early-stage career scientists to embark on fully independent research programs as an alternative to traditional postdoctoral studies. Recent PhD or MD graduates, within one year of graduation, with demonstrated excellence in research and leadership ability are appointed as Principal Investigators for an initial term of three years with the possibility for an extension of one to two additional years for a maximum of five years. Salk Fellow appointees are eligible for consideration for promotion to Assistant Professor. Salk Fellows are selected from a variety of disciplines, from biology, physics and mathematics to engineering, statistics and computer science, who have expertise in a...

  Assistant, Associate or Full Teaching Professor (LPSOE/LSOE/SR LSOE) - Computational Social Science, University of California San Diego The Division of Social Sciences at UC San Diego invites applications for a tenured or tenure-track Teaching Professor position in Computational Social Science, with a start date of July 1st, 2021. The position: A Teaching Professor is also known within the UC system as a Lecturer with (Potential) Security of Employment (L[P]SOE). The Teaching Professor series parallels that of the research-focused faculty series but with emphasis upon excellence in teaching and other instruction-related activities. Individuals in the position are expected to provide outstanding teaching, as well as to engage in professional activity and service related to the pedagogical mission of the program and university. This appointment confers membership in the Academic Senate. The Teaching Professor series includes security of employment analogous to...

Assistant Professor of Innovation, Technology, and Operations University of California San Diego The Rady School of Management ( http://rady.ucsd.edu/ ) at UC San Diego is committed to academic excellence and diversity within the faculty, staff, and student body. The Rady School invites applications for one or more faculty positions at the assistant professor level (tenure-track) in the field of Innovation, Technology, and Operations (ITO), subject to the availability of funds. Applicants must have a PhD or be working toward completion of a PhD in ITO or a related field by the start of the new academic year (July 2021). This position represents an Excellence Search for Diverse Faculty in Management initiative which seeks to recruit early-career faculty to the Rady School. This initiative seeks to build a more diverse faculty and aims to foster a diverse and inclusive community of scholars to enhance our academic and research missions. In addition to the highest...