221 jobs found

Position Description:   A postdoctoral researcher/bioinformatics specialist position is immediately available for three years to lead a project focused on tissue-specific and temporal variation in gene expression. The candidate will work in a highly collaborative team of researchers at Salk and at collaborating institutes in the U.S. Position Tasks: Compile large scale multi-tissue time-series gene expression data from rodents and non-human primates. Analyze full-length transcripts to find splice variants. Integrate gene expression and genome sequence data to find cis-acting elements. Integrate gene expression and genome sequence information to find allele specific gene expression. Comparative genomics between non-human primate, human, and rodent models. Integrate and analyze time-series gene expression and metabolomics datasets. Manage project to meet defined milestones and timeline. Coordinate efforts among the wet-lab and sequencing cores to ensure...

The McVicker laboratory studies how human genetic variation affects gene regulation by combining experimental approaches with computational analyses. We are especially interested in identifying pathogenic regulatory variants that act in immune cells and cancer cells. Currently, we are developing new tools to discover somatic regulatory mutations in cancer genomes, and manipulating cell lines with high-throughput CRISPR technologies to discover new regulatory sequences. In much of our research, we develop sophisticated computational and statistical methods so that we can extract subtle signals from noisy experimental data. Position Description:   Quantitative trait mapping of single cell gene expression and chromatin traits The McVicker Laboratory at the Salk Institute for Biological Studies is seeking a postdoctoral fellow to tackle cutting-edge research problems in genetics, gene regulation and chromatin biology. The successful candidate will develop new statistical...

The goal in the lab is to understand the molecular and circuit mechanisms of reward-based action learning, focusing on the cortico-basal ganglia circuitry and dopamine function. Position Description:   We are currently seeking a highly motivated and independent postdoctoral fellow interested in studying the basal ganglia circuits and behavior. Research in the laboratory focuses on the molecular and circuit mechanisms of action learning and selection, using a combination of behavioral, optogenetics, slice/in vivo electrophysiology and imaging techniques. The successful candidate will employ electrophysiology and/or deep-brain imaging, together with viral tracing and optogenetics to dissect the function of specific cell types of basal ganglia circuitry in freely behaving mice. Education:   The candidate should hold a doctoral degree with a strong background in systems or cellular neuroscience. Experience:   Experience on slice or in vivo electrophysiological...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. Description:   The Kosuri Lab at the Salk Institute for Biological Studies seeks to recruit multiple Postdoctoral Fellows to engage in integrative biology research. The lab has two tracks: 1) single-molecule studies of protein-DNA interactions, using methods based on DNA origami and super resolution microscopy; and 2) Cardiac biology studies in mouse models and humans, using genetic and imaging approaches including new methods for single-cell spatial transcriptomics. The postdoctoral positions are for scientists looking to invent and deploy new technology to uncover foundational principles in biology. Ideal candidates are excited to join a...

The research focuses on important problems related to cancer initiation, detection, progression, metastasis and treatment. These projects are based on our recent observations concerning cell state plasticity that arises during cancer progression. Specifically, we are using a single cell RNA sequencing, epigenetic profiling, and developing novel in vivo and in vitro strategies involving mouse models and organoid cultures to determine how cancer cells undergo developmental reprogramming to generate intra-tumoral heterogeneity and metastasis. We use computational methods based on mouse cancer models and human databases. Our work has focused significantly on breast cancer, but new studies have taken us into exciting directions involving cell state reprogramming involving acinar-ductal metaplasia in the genesis of pancreas cancer. Our long-term goals are to devise novel strategies to intercept cells undergoing reprogramming to reduce the probability that drug resistant or metastatic...

The Lyumkis Laboratory applies cryo-EM methods for structure determination of macromolecular assemblies involved in viral infection and chromatin regulation. The Manor Laboratory at the Waitt Advanced Biophotonics Center applies advanced imaging probes and microscopy techniques to visualize the inner workings of cells. We are seeking two postdoctoral candidates to work jointly with us, in conjunction with the cryo-EM facility at The Scripps Research Institute, to develop and apply novel imaging and analysis pipelines for coupling live cell dynamics with focused ion beam milling, cryo-ET, and image analysis of macromolecular assemblies in situ. Position Highlights:  Broadly involved in exciting projects to visualize macromolecular assemblies in cells using integrated structural and cellular biology approaches Utilize an array of advanced tools in live-cell and cryo-fluorescence microscopy, focused ion beam milling, cryo-electron tomography, machine learning and object...

The Chalasani lab at Salk is seeking ambitious and motivated post-doctoral fellows to join their Sonogenetics team. The goal of this project is to develop a new non-invasive method to manipulate neurons and non-neuronal cells ( www.sonogenetics.salk.edu ). Our manuscript demonstrating the efficacy of this method in mice was recently posted on bioarxiv ( https://www.biorxiv.org/content/10.1101/2020.10.14.338699v1 ).  We are planning to identify and validate new channel candidates and variants for use across model systems to achieve both excitation and inhibition non invasively.  Additionally, this project involves collaborating with engineers, bioinformaticians, protein biochemists and theoretical modelers.  We are particularly interested in individuals with expertise in electrophysiology (in vitro and in vivo) and/or mouse behavior and neural circuit analysis. Please contact the PI ( schalasani@salk.edu ) with your resume and names of referees who can speak to your skills.

The Engle Lab focuses on understanding the etiology of pancreatitis and pancreatic cancer to develop better prevention, diagnostic, and treatment strategies. We study the impact of altered glycosylation on the cross-talk between ductal cells with their microenvironment during disease pathogenesis as well as the role of tobacco-related carcinogens in priming the pancreas for transformation. We rely heavily on three-dimensional organoid mono- and co-culture systems as well as genetically engineered mouse models.  Position Description Post-doctoral positions are immediately available for individuals with a good understanding of cancer and disease modeling. Ideal candidates should be intellectually curious, well-organized and well-versed in constructive problem solving. Experience with cell culture and mouse modeling is preferred. Education:   Ph.D. or M.D./Ph.D. in Biological Sciences or related fields.  

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all positions (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. The Salk Institute Animal Resources Department (ARD) has one (1) position open for a Residency in Laboratory Animal Medicine (LAM) starting September 6th, 2021. The program is designed to prepare veterinarians for a career in LAM. The residency is approved by the American College of Laboratory Animal Medicine (ACLAM) and fulfills eligibility requirements for the ACLAM certifying examination. The resident will rotate within the ARD services and gain experience in the medical, surgical, anesthetic and behavioral management of a variety of laboratory animal models used at the Institute, including, but not limited to, mice, rats, rabbits, guinea pigs,...

Position description Our research employs cross-disciplinary approaches (genetics, transcriptomics, circuit tracing, functional imaging, quantitative behavioral analyses) to elucidate the roles played by genes and neurons in social behavior. An ideal postdoctoral fellow candidate would have a demonstrated expertise in the following fields: Biochemistry and bioinformatics. We seek a candidate who has both bench and quantitative data analysis experience in transcriptomics. Using our 10X Genomics single cell transcriptome platform, we intend to characterize genes responsible for flexible behavioral modulations during social interactions in both flies and unconventional animal models, such as honey bees and paper wasps. Neurophysiology. We seek a candidate who is familiar with techniques for monitoring activities of neurons in vivo , such as electrophysiology and functional imaging. We are in the process of expanding our functional imaging capacity to be able to monitor...

The Stites Laboratory applies quantitative and systems approaches (both experimental and computational) to the study of cancer.  We primarily focus upon the RAS pathway due to its importance in cancer, the abundance of data on the pathway and its molecular components, and the ready availability of excellent reagents and methods.  We repurpose these data and methods to study RAS and cancer from a systems perspective.   The laboratory is comprised of both experimental biologists and computational biologists.   Position Description:   The postdoctoral fellow will be the primary lead for one or more experimental research projects that investigate the RAS pathway in cancer.  Collaboration with other experimental scientists, as well as with computational scientists, is encouraged as part of this position. Education:   Ph.D. in Biological Sciences or equivalent. Experience:   Experience with cancer cell signaling, functional genomics, cancer biology, and/or...

Laboratory research focuses on how genes and molecules orchestrate the development of an embryo. The knowledge obtained may help to discover new molecules and specific gene/cell treatments to prevent and cure diseases affecting mankind both in the adult and embryonic stages, as well as inducing endogenous in vivo regenerative responses that may allow for tissue and organ regeneration and slowing down the aging process. Position Description:   Funded post-doctoral positions are immediately available for individuals with a good grounding in molecular and/or developmental biology, methods such as CRISPR mediated genome editing, RNA sequencing and epigenetics. Knowledge of bioinformatics is also very desirable. Ideal candidates should be intellectually curious, productive, and enjoy working in a committed team effort to make these important projects succeed. The projects are well under way due to the efforts of a dedicated group of post-docs, technicians and undergrads....

Description The Lyumkis laboratory is interested in deciphering how large nuclear proteins and protein complexes are assembled, how they functionally interact with one another, and how they engage chromatin to initiate distinct regulatory events. Using structural biology and biochemistry, we study multiple interconnected biological processes that broadly involve chromatin structure and its regulation, with direct relevance to human diseases. Our findings provide insight into basic biological mechanisms governing protein function, and there are also opportunities to translate findings into a clinical setting.  We are seeking an outstanding postdoctoral candidate to work with us to develop exciting directions in chromatin structural biology. We have established workflows for assembling and purifying different nucleosome substrates, producing proteins in insect and/or mammalian cells, and for high-resolution cryo-EM. The candidate will develop independent directions and will...

The Stites Laboratory applies quantitative and systems approaches (both experimental and computational) to the study of cancer.  We primarily focus upon the RAS pathway due to its importance in cancer, the abundance of data on the pathway and its molecular components, and the ready availability of excellent reagents and methods.  We repurpose these data and methods to study RAS from a systems perspective.   The laboratory is comprised of both experimental biologists and computational biologists. Position Description:   The postdoctoral fellow will be the primary lead for a new research program in the laboratory.  The research project(s) in this program will extend the lab's established expertise in RAS biology, cancer biology, personalized medicine, and computational systems biology into the field of synthetic biology.  Envisioned projects will utilize a synthetic biology approach to investigate cancer development and new cancer treatment strategies.  The postdoctoral...

Description The Michael Group in the Plant Molecular and Cellular Biology Laboratory at the Salk focuses on sequencing, assembling and analyzing plant genomes. A broad objective is to build genome resources for plants with unique morphological or lifestyle characteristics (carnivorous, parasitic), minimal plants (duckweed), and crop wild relatives (CWR), to better understand plant genome organization and trait architecture. Currently we are working on several different strategies to generate chromosome-level haplotype-resolved polyploid genomes. In addition, we are developing new techniques to annotate (coding and non-coding) non-model plant genomes using single-cell sequencing, direct DNA modification detection, and computational approaches. We are developing reference-free pan-genome methods for integration into genome wide selection studies (GWAS) and genomic selection paradigms to link population level phenotypes to gene networks underlying environmental response and...

Description The Manor Laboratory at the Waitt Advanced Biophotonics Center has been established at the Salk Institute for Biological Studies as a state-of-the-art research hub to provide advanced and emerging imaging modalities to enable unprecedented insights into the inner workings of cells, tissues and organisms. We are seeking a candidate with experience in hearing research to work with us to develop novel optogenetic mouse models, gene therapy approaches, and imaging technologies to study cochlear hair cell stereocilia dynamics in rodent and non-human primate model systems of hearing loss. To learn more about the lab here:   https://www.salk.edu/scientist/uri-manor/ Education: PhD or equivalent in Biological Sciences,  Cellular/Molecular Biology or related fields. Application Instructions:  send a short description of research interest and CV to umanor@salk.edu

Description A funded postdoctoral position is available under the joint mentorship of Drs. Uri Manor and John Reynolds at the Salk Institute for Biological Studies.  The goal of the project is to understand how changes in synapses and peri-synaptic mitochondria contribute to age-related cognitive decline.  The project is motivated by the observation that the vast majority of the brain's energy budget supports the synapse, which is the seat of learning and memory.  The energetic needs of the synapse are met predominantly by mitochondria, which both support synaptic plasticity and are, themselves, plastic, altering their form, function and position to meet the changing needs of the synapse during learning and synaptic transmission.  The project is highly collaborative, drawing on complementary expertise in learning and memory, primate behavior, neurophysiology, synaptic function, live cell imaging and electron microscopy.  The trainee will gain expertise in all of these areas,...

The laboratory of Dr. Daniel Hollern at the Salk Institute of Biological Studies Department of Immunobiology and Microbial Pathogenesis in La Jolla, California seeks to recruit a Postdoctoral Fellow to engage in immuno-oncology research. The main focus of the lab is to understand the immunological and molecular landscape of tumors with the goal of leveraging the immune component to promote anti-tumor immunity. In more detail, the lab is particularly interested in developing these approaches through the study of tumor infiltrating B cells and T cells. These studies will be pursued in syngeneic, orthotopic and genetically engineered mouse models as well as patient specimens.  The lab utilizes a multidisciplinary approach blending biologically appropriate models, molecular biology, and genomic analytical techniques including single cell and spatial transcriptomics and proteomics to interrogate pertinent questions in a number of in vitro and in vivo translational studies of breast...

We have multiple post-doctoral positions available in the Towers lab. Our work combines basic cell biology techniques and physiologically relevant cancer models to ask how cancer cells adapt when essential cellular recycling processes are blocked. We are looking for self-motivated and inquisitive scientist to join the team. Applicants should have a solid background in cancer biology and/or cell biology techniques with an eagerness to learn more. Additional skills in mouse models of cancer, optogenetics, cell metabolism, autophagy, and/or mitochondrial biology would be preferred.  To learn more about the lab here: https://towers.salk.edu/ Responsibilities: Perform investigational studies to understand how cancer models to ask how cancer cells adapt when essential cellular recycling processes are blocked. Perform cell biology experiments and/or perform in-vivo experiments in animal models such as mice or zebra fish. Execute experiments independently and contribute to...

The Division of Education at Governors State University in University Park, Illinois, United States, invites candidates to apply for a tenure-track assistant/associate professor position in the Educational Administration program to begin January 2022 or August 2022 (depending on candidate availability). This is a full-time, ten-month position. The position requires quality teaching, sustained scholarship, and productive service as defined by the contract. The programs served are in the Division of Education in the College of Education and primarily work with the master’s degree in Educational Administration (Principal Leadership), graduate certificate in Teacher Leadership, and Interdisciplinary Leadership doctoral program (Superintendent Leadership). The program is an institutional member of the International Council for Professors of Educational Leadership and their Illinois affiliate. Interested candidates must have 1) passion and commitment to develop leaders who will...