91 jobs found

Nearly every facet of human experience is colored by the sense of sight. The effortlessness and immediacy with which this sense conveys physical, social, and aesthetic qualities of one's environment belie the extraordinary complexity of the brain mechanisms involved. Our acute dependence upon these mechanisms is brought to the fore, however, by a variety of developmental, traumatic, and disease-related disorders of visual perception and visually-guided behavior. While rarely life- threatening, such disorders can be profoundly debilitating, impairing activities that we have come to take for granted, such as reading, driving, or recognizing family and friends. We seek a thorough understanding of brain mechanisms of visual information processing, with the promise of effective treatment and remediation of disorders of vision, as well as insights into the nature of our conscious experience of the world. The specific aims of our research have been to identify how...

Post-doctoral position available for individual interested in signal transduction, transcriptional regulation, and metabolism. Experience in RNA sequencing, chromatin immunoprecipitation, and in bioinformatics helpful. Candidate should enjoy working independently in a collaborative setting. Interest in metabolic physiology desirable; we have state of the art facilities to study the role of the CREB pathway in different metabolic states. Our lab also employs genetics to gain insight into the role of the CREB pathway in glucose and lipid metabolism as well as in the development of insulin resistance and type II diabetes. We use biochemical approaches to characterize regulatory components of the CREB pathway and to identify cellular CREB target genes that contribute to the underlying physiology. Mice with knockouts of CREB and CRTC family members in different tissues are employed to identify biological contexts in which this pathway is activated. Interested...

Laboratory research focuses on understanding the etiology of pancreatitis and pancreatic cancer to develop better prevention, diagnostic, and treatment strategies. This work focuses on leveraging changes to glycosylation and the cross-talk between ductal cells with their microenvironment during disease pathogenesis. We rely heavily on three-dimensional organoid mono- and co-culture systems as well as genetically engineered mouse models. Through collaborations with both clinicians and pharmaceutical companies, we will bridge the divide between basic science and patient care. Position Description Post-doctoral positions are immediately available for individuals with a good understanding of cancer and disease modeling. This position offers the opportunity to help build a team from the ground up in this newly opened laboratory. Ideal candidates should be intellectually curious, well-organized and well-versed in constructive problem solving. Experience with...

The goal in the lab is to understand the molecular and circuit mechanisms of reward-based action learning, focusing on the cortico-basal ganglia circuitry and dopamine function. Position Description:   We are currently seeking a highly motivated and independent postdoctoral fellow interested in studying the basal ganglia circuits and behavior. Research in the laboratory focuses on the molecular and circuit mechanisms of action learning and selection, using a combination of behavioral, optogenetics, slice/in vivo electrophysiology and imaging techniques. The successful candidate will employ electrophysiology and/or deep-brain imaging, together with viral tracing and optogenetics to dissect the function of specific cell types of basal ganglia circuitry in freely behaving mice. Education:   The candidate should hold a doctoral degree with a strong background in systems or cellular neuroscience. Experience:   Experience on slice or in vivo...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration.   POSITION SUMMARY The CRoPS project aims to develop crop plants that sequester more carbon via extensive root systems containing recalcitrant carbon polymers to fight climate change. A major component of this research is to phenotype plant traits for conducting genetic analysis and confirm trait changes of genetic changes. The Research Asst III will supervise at least one Research Asst I, and work with other members of the CRoPS project and the Busch laboratory to conduct screen root traits to identify genetic mechanisms that lead to optimal root systems for carbon sequestration, and assess phenotypes of genetically...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration.   POSITION SUMMARY Research Assistant II position will focus on protein and biochemistry. A successful candidate will work half of their time on independent projects and the other half on supporting postdoctoral researchers in the lab. The position will be responsible for establishing and utilizing protein expression systems (i.e., bacteria, insect cell and mammalian) and performing biochemical experiments. Position will be trained in specific techniques and methods in order to execute experiments that are broadly designed by post doc or PI and must be able to carry out and analyze experimental results independently. The overall...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Clinical Research Coordinator position will be working on all human studies in the Panda lab, with a focus on two major projects. The first is "Influence of time-restricted eating (TRE) on circadian regulation of glucose homeostasis and mitochondrial function in patients with Metabolic Syndrome." The second is "Optimizing circadian rhythms by regulating eating patterns to reduce cardiometabolic disease risk among firefighters." We are investigating the effect of time-restricted eating in improving health. ESSENTIAL FUNCTIONS (80%) Clinical Study Data Collection   Participant recruitment...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration.   POSITION SUMMARY The Research Assistant I position is responsible for performing gene sequencing techniques and general lab support.  Our laboratory works on many large-scale genomics projects and therefore has a considerable amount of automation involved in sequencing library construction.  This position requires much work with a robotic pipetting system to generate thousands of sequencing libraries each week.  Other duties include general laboratory maintenance, coordination with other labs and FACS core for cell sorting, participation in regular team meetings to discuss progress, and well-organized LIMS and data recording....

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration.   POSITION SUMMARY The Research Assistant II position is responsible for assisting with research in genetics and diseases in marmoset models. Working as part of a multidisciplinary team, she/he will assist in the transgenesis of marmosets and the analysis of the phenotype of the marmoset model, including neuroimaging, behavioral tests, stereotaxic injection, tissue collection and sectioning, immunohistochemistry, PCR, DNA and RNA extractions and genotyping. We are looking for a motivated individual willing to learn colony maintenance such as pedigree recording and the techniques required in assisting transgenesis of marmosets,...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Regulatory Laboratory at the Salk Institute uses data science tools to analyze large scale data ranging from genomics to human lifestyle datasets. The Bioinformatics Analyst I position will work closely with other members of the lab and the PI to advance both genomics and human behavior research projects. A significant effort will be on the collection, integration and analyses of human behavioral and physiological datasets collected from multiple sources including but not limited to smartphone, wearables, surveys, interviews, omics data and clinical test results. This position will leverage a wide range of...

Application Instructions: E mployment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration.   POSITION SUMMARY Incumbent is primarily responsible for processing laboratory glassware, producing and maintaining fly food inventories, and maintaining sterile tips and tube for laboratories.  This includes collecting and transporting glassware from laboratories to the SCRM for processing and then delivering clean glassware back to laboratories.  Incumbent is also responsible for processing fly food, tips, and tubes to ensure laboratories have adequate supplies to meet their needs.  Processing involves the operation of washers, drying ovens, autoclaves, and a dispensing pump.    ESSENTIAL FUNCTIONS (55%)...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY Leveraging extensive program management knowledge, the CRoPS (CO 2 Removal on a Planetary Scale) Project Manager acts as an operational advisor to a cross- functional team, in order to meet Institute and CRoPS program objectives. The Project Manager will organize all aspects of project activities and provide support to the science and team leaders by establishing timelines and budgets, tracking and coordinating efforts across teams, and facilitating effective information flow among stakeholders. Moreover, the Project manager will draft, write and edit reports and other documents to advance the CRoPS program....

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY   The Lab Coordinator is responsible for overall lab management duties in support of the assigned Principal Investigator's (PI) and their laboratories. Supervises and performs technical and administrative tasks.  Maintains adequate inventory of materials and equipment to ensure adequate supplies for experimental needs.  Responsible for pre-award and post-award services for the PI and research staff.  Assists in the development of grant budgets.  Maintains familiarity with federal and state grant rules and processes. Manages lab safety programs to insure compliance with all applicable regulations.  Assists...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Research Assistant II is responsible for research support and some lab management duties in support of the Principal Investigator's (PI) studies along with duties involving molecular biology, biochemistry, protein production, purification, and some tissue culture work. Duties include performing advanced molecular biology and biochemistry for protein production, purification, and for biochemical assays, as well as some tissue culture work in support of research projects, assisting the postdoctoral associates with experimental design and direction, assisting in hiring new staff, supervising lab staff (junior...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Research Assistant I position is responsible for performing various molecular biology, genetics, behavioral assays, cell and biochemistry techniques; C. elegans handling and maintenance in support of the Principal Investigator (PI) and lab research goals. Other duties include assisting with general laboratory maintenance, including equipment maintenance, and ordering of supplies, etc. (30%) Molecular and Cellular Biology, and Biochemistry Techniques Molecular cloning (Standard methods and Gibson cloning) Western blotting (Southern blotting optional, but desired) Purification and manipulation of...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Research Assistant is responsible for performing tasks and experiments in support of academic research projects. The position is responsible for maintenance of neurobiology techniques in support of the lab and the Principal Investigator's (PI) research goals. The RAI will be responsible for lab ordering. Manages the mouse colony and oversees other personnel conducting colony management and genotyping. Responsible for maintenance of molecular biology, cell culture, histological processing, microscopy and surgical supplies, equipment and facilities. Performs molecular biology and cell culture, brain sectioning,...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Research Assistant II is responsible for research support duties in support of the Principal Investigator's (PI) studies in collaboration with the Biophotonics Core at the Salk Institute for Biological Studies. This specific position is a joint position between the laboratories of Dr. Dmitry Lyumkis and Dr. Uri Manor, bridging structural virology and microscopy / imaging, in order to visualize and structurally define the dynamics of viral infections in cells. The primary work broadly involves mammalian tissue culture, virology, and imaging. Duties include general mammalian cell culture, maintaining and...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY Provides general administrative (executive level) support to multiple PIs and affiliated lab group including lab management, grant writing, editing and general administrative assistance. Uses initiative, resourcefulness and good judgment to handle a wide variety of administrative and support duties such as project management, addressing inquiries, maintaining filing systems, processing paperwork, composing correspondence and coordinating meetings and travel arrangements. Serves as liaison to Administrative units (Payroll, Human Resources, Grant administration, Computing, etc.). Coordinates with other executive...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY: Position available in the Hargreaves Lab for overall lab management duties in support of the Principal Investigator's (PI) studies. General lab maintenance duties include maintaining adequate inventory of materials and equipment to ensure adequate supplies for experimental needs, ordering supplies, taking inventory, upkeep and safety. Position is also responsible for performing various molecular biology, biochemistry, and cell biology techniques in support of lab and PI research goals. Range of duties include, but is not limited to: conducting procedures, modifying procedures as needed, data collection and...

Application Instructions: Employment History Include your last ten (10) years of employment history, or length of your employment history if less, including all position (even those that are not relevant to this position) and periods of unemployment. Incomplete information could disqualify you from further consideration. POSITION SUMMARY The Research Assistant III position will focus on managing the lab's activities in the cryo-electron microscopy (cryo-EM) facility, utilizing high-end equipment for cryo-EM, focused-ion-beam (FIB) milling, and light microscopy, performing computational image processing tasks, assisting users with data collection and analysis, training members of the laboratory, and managing the facility for the laboratory. A central component will be the day-to-day operation and management of the cryo-EM infrastructure, which includes multiple electron microscopes, a FIB milling instrument, a cryo-fluorescence microscope, as...