Research Associate/Postdoctoral Scientist - Translational Research (Immunology/Oncology)

  • Salk Institute for Biological Studies
  • La Jolla, San Diego, CA, USA
  • Jul 29, 2020
Full time   Biology/Biotechnology/Life Sciences

Job Description

    • Posted: July 20, 2020
  • Full-Time
  • Salk Main Campus

    La Jolla, CA, USA
    Salk Main Campus

    La Jolla, CA, USA
    +0 more less

Job Details


Laboratory employs the help of a small DNA virus, called adenovirus, to both understand and treat cancer. DNA viruses and tumor cells sabotage such controls to drive their respective pathological propagation, albeit with one small difference: In tumor cells the key cellular players are targeted via mutations, while in infected cells viral proteins achieve the same end. Not surprisingly, many of the cellular targets are the same. Dr. O'Shea's lab is exploiting this overlap to help address three key questions: What are the critical cellular targets and pathways that drive deregulated growth? What is the human growth deregulation program and how do we uncouple it for tumor therapy? Can we manipulate viruses as novel therapeutic agents that trigger the rapid lytic death of tumor cells but leave normal cells unharmed?

Position Description: 

The Salk Institute of Biological Studies is seeking an experienced Immunologist/ Oncologist to join a Translational Group with the responsibility of developing a new pipeline of virus-based therapeutics delivering immune modulatory payloads for the treatment of cancer. This is a “hands-on” scientist role focused on translational research that is well suited for postdoctoral scientists potentially interested in a transition to a biotech/industry setting. The successful candidate is expected to have a strong scientific background in immunology/oncology. Major activities will include:


  • Conceive and design new immune-stimulatory therapeutics using novel platform technology
  • Develop and execute in vitro assays to evaluate virus candidates for potency and immune activity.
  • Design and execute in vivo studies to evaluate efficacy of therapeutic virus candidates in cancer disease models.
  • Document, analyze, interpret and present results within a multi-disciplinary team environment.
  • Work closely with the research group, CRO’s and external collaborators.


Candidate should have a Ph.D. in Immunology/Oncology or related field.


  • Deep knowledge/expertise in immunology/immune oncology field.
  • Extensive experience performing xenograft and syngeneic or gene-edited mouse models of cancer is required.
  • Experience developing and executing cell-based assays.
  • Expertise in development of in vitro/in vivo/ex vivo assays to assess immune function.
  • Flow cytometry experience required.
  • Molecular biology experience is strongly preferred.
  • Excellent written and oral communication, organizational skills and time management.
  • Ability to work independently as well as collaboratively.
  • Adaptable to change and new challenges.

Application Instructions: 

Applicants should send curriculum vitae, statement of research interests and experience, and contact information for three references to:

Michael Lyman, PhD



Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information. 41 CFR 60-1.35(c)

Application Details

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