Research Assistant I - Molecular and Cell Biology Laboratory, Dr. Clodagh O'Shea

  • Salk Institute for Biological Studies
  • La Jolla, San Diego, CA, USA
  • Jul 10, 2020
Full time   Biology/Biotechnology/Life Sciences

Job Description


Job #: H150

Posted Date: July 8, 2020

Closes On: Open Until Filled

Job Title: Research Assistant I - Molecular and Cell Biology Laboratory, Dr. Clodagh O'Shea

Status: Regular Full Time

Benefits Eligible: Yes

Laboratory/Department: Molecular and Cell Biology Laboratory

Laboratory employs the help of a small DNA virus, called adenovirus, to both understand and treat cancer. DNA viruses and tumor cells sabotage such controls to drive their respective pathological propagation, albeit with one small difference: In tumor cells the key cellular players are targeted via mutations, while in infected cells viral proteins achieve the same end. Not surprisingly, many of the cellular targets are the same. Dr. O'Shea's lab is exploiting this overlap to help address three key questions: What are the critical cellular targets and pathways that drive deregulated growth? What is the human growth deregulation program and how do we uncouple it for tumor therapy? Can we manipulate viruses as novel therapeutic agents that trigger the rapid lytic death of tumor cells but leave normal cells unharmed?

Position Description:

The Research Assistant I position is responsible for assisting scientists within the Reinventing Biology and Medicine’s team in the execution of in vivo models to characterize novel therapies for cancer, diabetes, and auto-immune diseases. The focus of this position will be management of research breeding colonies and to help perform research animal models. The ideal candidate will have worked with animals previously, managed research mouse colonies, and is excited to learn how to conduct animal experiments. The candidate will be responsible for learning and assisting with all techniques associated with the models such as dosing through multiple routes, blood collection, tissue harvesting, IVIS animal imaging, inoculation of cells, etc.



  • Bachelor’s degree in biological sciences or equivalent work experience in lieu of degree.



  • 0-2 years of experience as a lab technician or equivalent related experience
  • Demonstrated experience with managing research animal colonies
  • Demonstrated experience with mouse handling, including routine husbandry


  • Experience with blood and tissue collection/sampling and routine injections (i.v., i.p., s.c.)
  • Demonstrated experience with tissue culture and aseptic technique
  • Experience with whole animal imaging (IVIS) preferred but not required
    Special Requirements:
    • Must be willing to work in an animal-related research environment.
    • Must be willing to work an adjusted schedule to support research needs.
    • Satisfactory completion of the Institute’s background investigation.
    • Must be willing to sign confidentiality agreement.

    Physical Requirements:

    This position requires constant adjusting focus, grasping, hearing, keying, analyzing, calculating, communicating, reading, reasoning, writing, working inside and in confined areas.


Application Details


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Application Deadline

Open Until Filled