Postdoctoral Fellow - Clayton Foundation Laboratories for Peptide Biology, Dr. Marc Montminy

  • Salk Institute for Biological Studies
  • La Jolla, San Diego, CA, USA
  • Apr 13, 2020
Full time   Biology/Biotechnology/Life Sciences

Job Description

Job #: F259
Posted Date: December 28, 2019
Closes On: Open Until Filled
Job Title: Postdoctoral Fellow - Clayton Foundation Laboratories for Peptide Biology, Dr. Marc Montminy
Status: Regular Full Time
Benefits Eligible: Yes
Laboratory/Department: Clayton Foundation Laboratories for Peptide Biology
Our laboratory studies how extracellular signals trigger changes in metabolic energy balance via the activation of specific genetic programs. A number of growth factors and hormones activate cellular gene expression via the phosphorylation of key transcription factors and coactivators. As the first nuclear factor shown to be regulated by phosphorylation, CREB has been found to control a variety of processes as diverse as glucose metabolism and long-term memory. CREB and its coactivators trigger the expression of distinct cellular genes in different tissues following their induction in response to calcium and cAMP signals. Current work in the lab focuses on the identification of CREB target genes that mediate physiologic effects of this pathway in metabolic tissues such as liver, pancreatic islets, adipose tissue.
Position Description:

Post-doctoral position available for individual interested in signal transduction, transcriptional regulation, and metabolism. Experience in RNA sequencing, chromatin immunoprecipitation, and in bioinformatics helpful. Candidate should enjoy working independently in a collaborative setting. Interest in metabolic physiology desirable; we have state of the art facilities to study the role of the CREB pathway in different metabolic states. Our lab also employs genetics to gain insight into the role of the CREB pathway in glucose and lipid metabolism as well as in the development of insulin resistance and type II diabetes. We use biochemical approaches to characterize regulatory components of the CREB pathway and to identify cellular CREB target genes that contribute to the underlying physiology. Mice with knockouts of CREB and CRTC family members in different tissues are employed to identify biological contexts in which this pathway is activated. Interested applicants with PhD or MD degree and interest in signaling, transcription, bioinformatics, or metabolic physiology are encouraged to send their CV.

Application Instructions: Applicants should submit a current CV and names of three references to:

Marc R. Montminy, M.D., PhD
Clayton Foundation Laboratories for Peptide Biology
Salk Institute for Biological Studies
10010 North Torrey Pines Road
La Jolla, CA 92037


Application Details

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Application Deadline

Open Until Filled