Laboratory Manager, Department of Pathology and Laboratory Medicine

  • Brown University
  • Providence, RI, USA
  • Nov 16, 2022
Full time Biology/Biotechnology/Life Sciences Medicine & Dentistry Grants, Sponsored Programs, Research Health & Medical Services Other Administrative Positions

Job Description

 

Laboratory Manager

Department of Pathology and Laboratory Medicine

Brown University | Providence, Rhode Island

The Laboratory Manager is responsible for lab management, lab operations, lab member training, lab safety and lab maintenance. Further, this position is responsible for coordinating translational science collaborations and to develop and analyze patient and donor derived tissue samples and cell cultures via biochemical, immunological, and functional analyses. Finally, this position is responsible for managing databases for Lab Equipment, DNA stocks, RNA stocks and human/mouse cell stocks in support of a large cancer biology research lab in the Department of Pathology and Laboratory Medicine and the Legorreta Cancer Center at Brown University.

Research in Dr. Robert Sobol’s lab focuses on mechanisms of DNA repair, PARP and NAD+ metabolism in human cells and the convergent role of these pathways in response to environmental genotoxins and chemotherapy. A major goal in the lab is to use biochemical, genetic, and imaging modalities to study DNA repair protein complexes that respond to DNA damage induced by environmental genotoxins and chemotherapy and how this pathway affects the regulation of cellular metabolism via ADP-ribosylation signaling and alterations in NAD+ metabolism.  Recent efforts have focused on the role of DNA repair pathways and the regulation of PARP1/PARP2 activation in response to replication stress, identification of novel targets to overcome PARP-inhibitor resistance and the development of novel biological tools and assays to evaluate genotoxic stress and PARP-activation that may be used for the discovery of novel compounds that may be used in the treatment of cancer and evaluating genotoxin response.

Techniques used in the lab include the genetic manipulation of cells in culture, genetic and epigenetic analysis of tumor cells, development and phenotypic characterization of transgenic cells, development and characterization of transgenic mice, RNA interference, CRISPR/cas9 gene editing, lentivirus production and viral transduction of mouse and human cells, molecular cloning of mouse and human cDNAs, DNA damage and repair assays, cell culture, cell cytotoxicity assays and PCR.

This is a fixed term position with a current end date of one year from hire, which may be extended based upon available funding.

 

 

Preferred and Required Qualifications

Education and Experience

Bachelor’s degree in Molecular Biology, Biology, or related field required.

Master’s degree preferred.

At least 5-7 years’ experience working in organized research, or equivalent combination of education and experience required.

2 years’ experience bench research preferred.

Experience in culturing human primary cells and development of primary cell lines from human tumors is preferred.

Experience in immunoblotting, immunohistochemistry, and qRT-PCR preferred.

Job Competencies

High level of discretion to prioritize workflow and experimental methodologies.

High level communication skills with all levels of laboratory staff and collaborators.

 

Excellent computer skills including databases and spreadsheets.

High level of initiative and ability to work independently as well as collaboratively with a diverse group of people, with vastly different skills and training.

Working some weekends and evenings may be required based on laboratory/experiment needs.

Possesses willingness and ability to support a diverse and inclusive campus community.

Criminal and education background check required.

Vaccination Requirements:

In order to maintain 90% or greater universal vaccination rates on campus, all newly hired employees at Brown University must receive the final dose of the COVID-19 vaccine before they begin work, unless they are approved for a medical or religious exemption. All employees must also receive a COVID-19 booster within thirty (30) days of becoming eligible. For more information, please visit the Healthy Brown site.

Application Details

To apply, please use this link to directly view the position on Brown’s Career Site: https://brown.wd5.myworkdayjobs.com/staff-careers-brown/job/70-Ship-Street/Laboratory-Manager_REQ183114-1

Brown University is committed to fostering a diverse and inclusive academic global community; as an EEO/AA employer, Brown considers applicants for employment without regard to, and does not discriminate on the basis of, gender, race, protected veteran status, disability, or any other legally protected status.

About Brown (Please visit our website and get to know us better at: www.brown.edu)

Located in historic Providence, Rhode Island and founded in 1764, Brown University is the seventh-oldest college in the United States. Brown is an independent, coeducational Ivy League institution comprising undergraduate and graduate programs, plus the Alpert Medical School, School of Public Health, School of Engineering, and the School of Professional Studies.

With its talented and motivated student body and accomplished faculty, Brown is a leading research university that maintains a particular commitment to exceptional undergraduate instruction. Brown’s vibrant, diverse campus community consists of about 4,500 staff and faculty, 6,200 undergraduates, 2,000 graduate students, 490 medical school students, more than 5,000 summer, visiting, and online students, and over 700 faculty members. Brown students come from all 50 states and more than 115 countries. Brown is frequently recognized for its global reach, many cultural events, numerous campus groups and activities, active community service programs, highly competitive athletics, and beautiful facilities located in a richly historic urban setting.

Brown offers competitive benefits such as a generous retirement plan and education programs; details are available at: http://www.brown.edu/about/administration/human-resources/

 


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