Post Doc Positions in Human Liver Microphysiology Systmes(MPS)

  • University of Pittsburgh, Office for Equity, Diversity, and Inclusion
  • Pittsburgh, PA, USA
  • May 04, 2022
Full time Medicine & Dentistry Postdoctoral Positions

Job Description

 

Post-Doctoral Positions in Human Liver Microphysiology Systems (MPS)

Pitt Talent Center Job ID: 21007417 (https://www.join.pitt.edu/)

In the Drug Discovery Institute (Pittsburgh Technology Center), D. Lansing Taylor, Ph.D., Director, University of Pittsburgh Drug Discovery Institute (UPDDI) Distinguished Professor and Allegheny Foundation Professor of Computational and Systems Biology

 

Job Description

The UPDDI is searching for two Postdoctoral Fellows for our biomimetic human liver MPS programs including testing predicted drugs for NAFLD, Type 2 Diabetes, liver as a metastatic niche, biologics induced liver injury, creating a predictive preclinical trial for NAFLD using patient-derived iPSCs and bioprinting chips with matrix materials and cells.  We are using 4-6 cell types (hepatocytes, liver sinusoidal endothelial cells, stellate cells, Kupffer cells and we add a variety of immune cells).  We are also beginning to incorporate cholangiocytes in some projects. As a mature reference model, we use primary human cells and in parallel are implementing iPSC-derived cells from genotyped patients.  As an example, one project is focused on studying mechanisms of NAFLD disease progression, the identification of disease-relevant biomarkers, and the testing of novel NAFLD drug candidates [Saydmohammed M., et al. Exp Biol Med (2021); PMID: 33957803 and Gough A., et al. Nat Rev Gastroenterol Hepatol. (2021); PMID: 33335282] and Lefever, et. al. (in review). In parallel, we are developing a preclinical trial platform to optimize selection of patient cohorts for clinical trials by testing genetic variants. Great talent in cell-based experimentation, knowledge of liver physiology and the use of imaging systems is required. Biomedical engineers with experience in the design and application of liver MPS systems are also strongly encouraged to apply. This is an excellent opportunity to participate in a highly collaborative team of bio- engineers, cell and molecular biologists, computational biologists, pharmacologists, and clinician-scientists to apply our MPS models of disease to drug discovery. We are implementing a platform focused on human biomimetic liver microphysiology systems (MPS) both alone and coupled to other organ chips that uses functional genomic, biochemical, and phenotypic metrics, the microphysiology systems database (now BioSystics-Analytics Platform) and quantitative systems pharmacology (QSP).

 

Start Date: Summer 2022

Funding from NIH-NCATS, NIH-NIDDK, and NIH-CTSA

 

 

Position Responsibilities

  • Optimize and validate the application of the human, 4-6 cell-type LAMPS and vLAMPS model of NAFLD with various drug treatments and interpret the biochemical, biosensor, molecular and pathology read-outs.
  • Collaborate with the liver microphysiology systems team and clinician-scientists at Pitt.
  • Design, plan and execute experiments; analyze and present results in seminars and publications.

 

 

The University of Pittsburgh requires all Pitt constituents (employees and students) on all campuses to be vaccinated against COVID-19 or have an approved exemption. Visit coronavirus.pitt.edu to learn more about this requirement.

 

 

  The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity, and diversity. EOE, including disability/vets 

 

To apply: Job Description - Post Doctoral Associate (21007417) (taleo.net)

Preferred and Required Qualifications

Experience and Training

  • Ph.D in physiology, cell biology, biophysics, biomedical engineering, or related field
  • Strong cell-based research experience; previous experience with liver MPS model systems or co-culture systems is highly valued.
  • Experience in liver cell and organ physiology, cell and molecular biology and fluorescence imaging is highly desired
  • Experience with primary (patient isolated) human cells and iPSCs a plus.

 

Application Details

Start date - Summer 2022

The University of Pittsburgh requires all Pitt constituents (employees and students) on all campuses to be vaccinated against COVID-19 or have an approved exemption. Visit coronavirus.pitt.edu to learn more about this requirement.

 

 

  The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity, and diversity. EOE, including disability/vets 

 

To apply: Job Description - Post Doctoral Associate (21007417) (taleo.net)


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