Director, Next Generation Sequencing Core Facility

  • Salk Institute for Biological Studies
  • La Jolla, CA 920371002, USA
  • Apr 25, 2022
Full time Biology/Biotechnology/Life Sciences

Job Description

The Next Gen Sequencing Core (NGS) provides services and access to genomic & transcriptomic technologies to Salk Institute researchers. This position will be responsible for, with limited guidance, independent oversight and execution of a full range of duties supporting and developing core facility operations, administration, methods development and outreach that are envisioned to have this shared scientific resource meet the existing and developing research needs in this rapidly expanding and leading-edge technology field. The Director will also be expected to participate in grant writing, preparation of manuscripts, identifying and obtaining funding opportunities in connection with Salk research groups. Additionally, the Director will support the Executive Director, Research Operations on overarching initiatives for Core Facilities as appropriate.

This position is intended to serve as a technical expert and functional leader. The incumbent will have overall responsibility for the management and formation of the core facility, its programs, and systems. The Director will serve as lead developer, administrator, technical lead and division manager. Incumbent is responsible for planning, design, development, implementation and maintenance of facility. The Director will also be responsible for the supervision of NGS Core staff.


 (40%) Research Support

  •  Work with Salk researchers to achieve targeted research goals utilizing NGS technology platforms.
  • With the support of faculty sponsors, the incumbent evaluates new techniques and technology as needed or requested by PI or as dictated by advances in the field. 
  • Identify/test/compare/optimize new protocols / reagents for use on core instrumentation. 
  • Provide collaborative support to experiment design and implementation for new and existing approaches to using NGS technologies. participate in generation of manuscripts and grant applications. 
  • Provide expert consultation on experimental design and use of NGS technologies. 
  • Develop new in-house protocols and assist with troubleshooting on execution of existing protocols for NGS applications. 
  • Work with institute staff on complex research projects, providing research tools, testing, training and other services to the campus.
  • Write relevant technical reports and present research work internally and externally. 
  • Keep up to date with the state-of-the-art in next generation sequencing technologies by review of relevant literature and attendance at scientific meetings. 
  • Work closely with the Director of IGC-Bioinformatics core to develop and implement best practices for NGS data transfer, analysis and storage. Review the latest in technology (hardware, software and networking) and ensure that recommendations for changes or upgrades will integrate well with existing NGS core technologies. 
2)  (40%) Core Facility Management
  • Provide leadership and vision to ensure proper scientific procedures and systems are implemented and followed. 
  • Oversee all aspects of NGS department management and ensure the coordination and effective operation of the core facility including maintenance of equipment, interactions with core users, and effective use of core resources. 
  • Reviews operational needs and develops and implements intermediate and long term goals. Ensure department time lines are maintained and that benchmarks and milestones are met. 
  • Develop laboratory guidelines; maintain procedures manuals; and evaluate new materials and equipment. 
  • Serve as liaison with other departments including Accounting, HR, Admin Services, and Facilities Services to ensure core and institutional needs are met. 
  • Recruit, screen, interview candidates and select core personnel in accordance with State and Federal laws, Institute personnel policies and procedures. 
  • Train and assign work to new and continuing employees. 
  • Independently supervise and conduct performance evaluations, recommend salary increases, merits and reclassifications.
  • Responsible for overseeing the generation of monthly recharge reports and external accounts payable invoices for external customers. Monitors all invoices to confirm/ensure payments. 
  • Responsible for assuring that effective communication with PI's, lab managers and administrative assistants is carried out with respect to core services and confirm/ensure payments. 
  • Works close with faculty sponsors and executive director to assure optimal reporting and interactions with funding agencies and recharges.
  • Participates in development and oversight of NGS core budget and recharge rates.
3)   (20%) Institutional Support
  • Develop and administer teaching/training seminars on aspects of the NGS technology that are pertinent to current or potential Institute research  needs. 
  • Take lead on outreach activities including seminar style information course(s), organization of internal and external seminars, office hours and individual consultations on methods related to NGS technologies. 
  • Work with executive director and Development department to give lay audience presentations, small group and individual discussions/tours of the NGS Core, the technology and applications to Salk research. 
  • Contribute to grant writing efforts in support of advancing NGS technology advancement at the Institute. 
  • Work with the Office of Technology Development at Salk to advance potential intellectual property and discoveries that could be promising candidates for patents and/or licensing for external use. 


  •  7 or more years of related progressively complex experience, with at least 3 of those years in a lead or management capacity. 
  • Experience in the design, execution and analysis of next generation sequencing experiments on a diverse range of current technology platforms. 
  • Experience and detailed understanding of a range of sequencing platforms including Illumina Short Read sequencing as well as PacBio and Oxford Nanopore long read sequencing platforms.
  • Experience and detailed understanding of a range of methodologies utilizing NGS technology including, but not limited to, Single Cell Sequencing, RNA-Seq, ChIP-Seq, GRO-Seq, Bisulfite Sequencing, Hi-C, ATAC-Seq, Cut&Run/Tag, CRISPR screening, WGS (whole genome sequencing), ISO-Seq and amplicon sequencing as well as sample QC and a broad range of sample preparation methods consistent with the technology platforms supported by the NGS Core.
  • Demonstrated experience to execute complex experiments and techniques with reliability and accuracy while working within time constraints. 
  • Demonstrated experience establishing and managing efficient, cost-effective high- throughput sequencing workflows.
  • Demonstrated experience to lead multidisciplinary teams to complete NGS projects. 
  • Demonstrated experience in drafting grant and proposal materials related to instrument and core operational support acquisition. 
  • Demonstrated administrative experience in a science department or equivalent experience with proven ability to analyze, interpret and apply management principles, practices and techniques for a large, multi-disciplinary academic/research organization. 
  •  Experience drafting and implementing standard operating procedures to achieve reproducible and traceable results for NGS experiments is important for this position.
  • Experience with spatial genomics technologies.


  • Ph.D. in molecular or cellular biology, genetics, physics, chemistry, or biochemistry or equivalent combination of education and experience.


  • Demonstrated ability to develop, execute and optimize cutting-edge next-generation sequencing(NGS)-based methods. 
  • Well versed in using NGS analysis software and downstream data analysis. 
  • Ability to perform highly complex experiments and techniques with high levels of reliability and accuracy within time constraints. 
  • Excellent customer service and interpersonal skills. Interpersonal skills include tact, good judgment, diplomacy and flexibility to relate to a diverse group of scientific research staff, faculty, executive management, administrative staff and external contracts. 
  • Demonstrated ability to work independently, prioritize work and independently manage multiple, diverse and competing priorities while meeting deadlines; plan and develop goals.
  • Ability to work with autonomy within a controlled environment with shifting priorities and timelines. Ability to work in a collaborative, team environment.
  • Ability to review goals, analyze processes necessary to achieve those goals, and develop techniques and systems required to meet those goals. Often explores new areas and seeks opportunities to apply new knowledge to work.
  • Strong verbal communications skills to effectively understand or interpret technical requests and or/ problems conveyed by others and respond accordingly.
  • Strong written communication skills required for grant writing, progress reports, and documentation of protocols.
  • Proven managerial ability to provide direction to staff in accomplishing goals and objectives, and to maintain core facility activities with respect to established procedures and guidelines. Proven ability to hire, train, supervise, evaluate and discipline staff.
  • In-depth understanding of organizational structure both within and outside the work unit, including the role of each position in the group and in other groups.
  • Able to critically review information and understands new concepts with minimal assistance.
  • Demonstrated experience with budgets and financial functions including accounting and budgeting skills. Knowledge of methods and procedures used in collecting, analyzing, interpreting and reporting data. Ability to develop and monitor budget data.
  • Must be willing to work in an animal-related research environment. 
  • Must be willing to work an adjusted schedule to support research needs. 
  • Successful completion of the Institute's background investigation. 

This person will be constantly adjusting focus, seeing, analyzing, communicating, reading, reasoning, writing and working inside. 

Application Details

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