The Lyumkis laboratory is interested in deciphering how large nuclear proteins and protein complexes are assembled, how they functionally interact with one another, and how they engage chromatin to initiate distinct regulatory events. Using structural biology and biochemistry, we study multiple interconnected biological processes that broadly involve chromatin structure and its regulation, with direct relevance to human diseases. Our findings provide insight into basic biological mechanisms governing protein function, and there are also opportunities to translate findings into a clinical setting.
We are seeking an outstanding postdoctoral candidate to work with us to develop exciting directions in chromatin structural biology. We have established workflows for assembling and purifying different nucleosome substrates, producing proteins in insect and/or mammalian cells, and for high-resolution cryo-EM. The candidate will develop independent directions and will also work closely within a collaborative team of scientists to advance common goals.
The ideal candidate will be familiar with:
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