Research Specialist C/D

Research Specialist C/D

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Posted Job Title
Research Specialist C/D

Job Profile Title
Research Specialist C

Job Description Summary
The Research Specialist C/D position in The Center for Cellular Immunotherapies will support research efforts in CAR T-cell therapy development by performing complex in vitro and in vivo experiments.

Job Description

Job Responsibilities

In vitro experiments

• Prepare cell culture materials, media, and reagents.
• Follow established protocols and maintain accurate experimental records.
• Isolate, transduce, transfect, electroporate, expand, formulate, and cryopreserve human T lymphocytes. Perform in vitro experiments to assess T cell phenotype and function (flow cytometry and cocultuure assays).
• Perform molecular assays, optimize experimental conditions.
• Follow standardized protocols and optimize methods to establish in vivo tumor models (IP, IV, orthotopic, subcutaneous) and monitor responses to various cell therapies.
• Perform injections, tumor measurements, imaging, bleeding, necropsy, and tissue harvesting.

Data Acquisition, Analysis, Summarization, Reporting/Presentation

• Maintain organized, real-time records of experiments for traceability and reproducibility.
• Keep accurate data records into laboratory notebooks and group folders and provide data as needed.
• Present data to supervisor and in small group meetings.

General support to laboratory

• Maintain laboratory organization and inventory.
• Collaborate with team members to achieve research goals.
• Ensure compliance with ethical standards and proper handling of animals and hazardous materials.

In addition to the duties listed, the Research Specialist D will design panels and perform multiparametric flow cytometry for phenotypic characterization of engineered T cells and co-cultures; analyzes datasets using appropriate software. Design, plan and carry out molecular assays. Independently develop protocols, ensure data collected is verified, complete and consistent and properly recorded in digital folders and lab notebook. Provides data summaries, tables, graphs and figures for reports and presentations. Train students and new members on general laboratory procedures, providing advice and mentorship on technical procedures

Qualifications

Research Specialist C

• Bachelor of Science and 3 to 5 years of experience or equivalent combination of education and experience is required.
• Demonstrated proficiency in tissue culture techniques and basic molecular biology methods.
• Extensive in vivo experience with mouse models, including NSG/syngeneic tumor modeling, intravenous (IV),
• Ability to follow established protocols accurately and maintain detailed records.
• Strong organizational skills and ability to work collaboratively in a team environment

Qualifications preferred:

• Experience with molecular biology techniques, including gene editing and cloning.
• Familiarity with CAR T-cell manufacturing processes and human primary lymphocyte cultures.
  
  
• Experience with imaging modalities for tumor monitoring.

Research Specialist D

Master's degree (Biology, Immunology, or a related scientific discipline) and 3 to 5 years of experience, or an equivalent combination of education and experience.

Demonstrated proficiency in flow cytometry, including panel design, multiparametric analysis, and data interpretation.

Extensive in vivo experience with mouse models, including NSG/syngeneic tumor modeling, intravenous (IV), intraperitoneal (IP), and orthotopic injections, tumor measurements, blood sampling, and tissue harvesting.

Strong analytical and decision-making skills to implement assigned projects and troubleshoot technical issues.

Ability to work independently to manage daily research projects, data collection, and laboratory organization.

Excellent organizational and record-keeping skills; ability to manage multiple projects simultaneously.

Strong communication skills and ability to work collaboratively in a team environment.

Preferred:

-Experience with molecular biology techniques, including gene editing and cloning.

Familiarity with CAR T-cell manufacturing processes and human primary lymphocyte cultures.

Experience with imaging modalities for tumor monitoring.

Ability to analyze and present data using statistical and graphing software.

Position is contingent upon continued funding.

Job Location - City, State
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$57,500.00 - $78,000.00 Annual Rate
Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, and in alignment with salary ranges based on external market data for the job's level. Internal organization and peer data at Penn are also considered.

Equal Opportunity Statement

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state or local law.

Special Requirements
Background checks may be required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

University Benefits

• Health, Life, and Flexible Spending Accounts: Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.
• Tuition: Take advantage of Penn's exceptional tuition benefits. You, your spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other institutions.
• Retirement: Penn offers generous retirement plans to help you save for your future. Penn's Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options through TIAA and Vanguard.
• Time Away from Work: Penn provides you with a substantial amount of time away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with family-whatever your personal needs may be.
• Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services received at home, in the community or in a nursing facility. If you apply when you're newly hired, you won't have to provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to underwriting.
• Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as they balance the competing demands of work and personal life. That's why we offer a wide variety of programs and resources to help you care for your health, your family, and your work-life balance.
• Professional and Personal Development: Penn provides an array of resources to help you advance yourself personally and professionally.
• University Resources: As a member of the Penn community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University's libraries and athletic facilities, or visit our arboretum and art galleries. There's always something going on at Penn, whether it's a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few examples. As a member of the Penn community, you're right in the middle of the excitement-and you and your family can enjoy many of these activities for free.
• Discounts and Special Services: From arts and entertainment to transportation and mortgages, you'll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.
• Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.
• Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.
• Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.

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To learn more, please visit: https://www.hr.upenn.edu/PennHR/benefits-pay


Equal Employment Opportunity Statement

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.
To apply, visit https://wd1.myworkdaysite.com/en-US/recruiting/upenn/careers-at-penn/job/Smilow-Center-for-Translational/Research-Specialist-C-D_JR00114694-1









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